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Essential oils, lavender

General Material Information

Trival Name	Essential oils, lavender
Short Description	essential oil distilled from the flowering herbs of the lavender, lavandula angustifolia, labiatae greece
CAS Number	8000-28-0
FDA UNII	Search
MDL	MFCD00147392
FEMA Number	2622
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	8000-28-0 ; LAVENDER, OIL (LAVANDULA OFFICINALIS CHAIX)
Applications	flavor and fragrance agents
Synonyms	essential oil distilled from the flowering herbs of the lavender, lavandula angustifolia, labiatae greece lavandula angustifolia herb oil greece lavandula officinalis herb oil greece lavandula spica herb oil greece lavandula vera herb oil greece lavender oil greece Essential oils, lavender Oils, lavender Oils, essential, lavender Lavandula, essential oil Lavender oil Oil of Lavender Oils, Lavandula officinalis Lavandula oil Oils, lavender oil Essential lavender oil Lavender essential oils Aromaya Raben Bontoux 1421 Lavender HP 83747 Lavender Liq. Lavandox Lavander French HA YH 99005 Silexan Lavandula officinalis oil YJ 1070-2 Lavender Liquid Oils, Lavandula angustifolia Lavandula aetheroleum LDY 1126

Occurrences

lavender

Organoleptic Properties

Odor Type: Floral
Odor strength	medium
Substantivity	12 hour(s) at 100.00 %
General comment	At 100.00 %. lavender floral herbal woody
Flavor Type: Herbal
General comment	Lavender

Potential Uses

Cosmetic purposes

Perfuming agents

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

	lavandula angustifolia l. herb oil
Canada Domestic Sub. List:	8000-28-0
Pubchem (sid):	135362275

Publications by PubMed
Rhamnolipids as emulsifying agents for essential oil formulations: Antimicrobial effect against Candidaalbicans and methicillin-resistant Staphylococcus aureus.
Oviposition deterrent and ovicidal activities of seven herbal essential oils against female adults of housefly, Musca domestica L.
Antibacterial activity against Clostridium genus and antiradical activity of the essential oils from different origin.
Membrane disruption and anti-quorum sensing effects of synergistic interaction between Lavandula angustifolia (lavender oil) in combination with antibiotic against plasmid-conferred multi-drug-resistant Escherichia coli.
Insecticidal activity of plant essential oils against the vine mealybug, Planococcus ficus.
Presence of monoterpene synthase in four Labiatae species and Solid-Phase Microextraction- Gas chromatography-Mass Spectroscopy analysis of their aroma profiles.
Effect of lavender inhalation on the symptoms of primary dysmenorrhea and the amount of menstrual bleeding: A randomized clinical trial.
Comparative studies of cytotoxic and apoptotic properties of different extracts and the essential oil of Lavandula angustifolia on malignant and normal cells.
Effect of lavender oil (Lavandula angustifolia) on cerebral edema and its possible mechanisms in an experimental model of stroke.
Biochemical composition and antioxidant properties of Lavandula angustifolia Miller essential oil are shielded by propolis against UV radiations.
A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia.
Evaluation of the effect of aromatherapy with lavender essential oil on post-tonsillectomy pain in pediatric patients: a randomized controlled trial.
A Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing.
Increased seizure latency and decreased severity of pentylenetetrazol-induced seizures in mice after essential oil administration.
The In Vitro Antimicrobial Activity of Lavandula angustifolia Essential Oil in Combination with Other Aroma-Therapeutic Oils.
Does lavender aromatherapy alleviate premenstrual emotional symptoms?: a randomized crossover trial.
Anosmia does not impair the anxiolytic-like effect of lavender essential oil inhalation in mice.
Distillation time effect on lavender essential oil yield and composition.
Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission.
Control of the chewing louse Bovicola (Werneckiella) ocellatus in donkeys, using essential oils.
Characterization of anxiolytic and neuropharmacological activities of Silexan.
Randomized controlled trial for Salvia sclarea or Lavandula angustifolia: differential effects on blood pressure in female patients with urinary incontinence undergoing urodynamic examination.
Neuroprotective effects of inhaled lavender oil on scopolamine-induced dementia via anti-oxidative activities in rats.
Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue.
Neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice.
The effects of clinical aromatherapy for anxiety and depression in the high risk postpartum woman - a pilot study.
Effects of lavender oil inhalation on improving scopolamine-induced spatial memory impairment in laboratory rats.
Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods.
[Sensitivity assessment of thyme and lavender essential oils against clinical strains of Escherichia coli for their resistance].
Toxicity of essential and non-essential oils against the chewing louse, Bovicola (Werneckiella) ocellatus.
Cloning and functional characterization of β-phellandrene synthase from Lavandula angustifolia.
[Effects of aromatherapy on changes in the autonomic nervous system, aortic pulse wave velocity and aortic augmentation index in patients with essential hypertension].
Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model.
An attempt of postharvest orange fruit rot control using essential oils from Mediterranean plants.
Physical properties of gum karaya-starch-essential oil patches.
Essential oil composition and larvicidal activity of six Mediterranean aromatic plants against the mosquito Aedes albopictus (Diptera: Culicidae).
Biodegradable gelatin-chitosan films incorporated with essential oils as antimicrobial agents for fish preservation.
The study protocol of a blinded randomised-controlled cross-over trial of lavender oil as a treatment of behavioural symptoms in dementia.
Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats.
Lavandula angustifolia essential oil as a novel and promising natural candidate for tick (Rhipicephalus (Boophilus) annulatus) control.
Antibacterial activity of essential oils from palmarosa, evening primrose, lavender and tuberose.
A genomics resource for investigating regulation of essential oil production in Lavandula angustifolia.
Effects of ultraviolet radiation on the kinetics of in vitro percutaneous absorption of lavender oil.
Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors.
The antimicrobial activity of high-necrodane and other lavender oils on methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA).
Lavandula angustifolia Miller: English lavender.
Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.
Improved microwave steam distillation apparatus for isolation of essential oils. Comparison with conventional steam distillation.
Comparative chemometric analyses of geographic origins and compositions of lavandin var. Grosso essential oils by mid infrared spectroscopy and gas chromatography.
Analysis of the volatile compounds of flowers and essential oils from Lavandula angustifolia cultivated in Northeastern Italy by headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry.
Cloning and functional characterization of three terpene synthases from lavender (Lavandula angustifolia).
Repellence of the red bud borer Resseliella oculiperda from grafted apple trees by impregnation of rubber budding strips with essential oils.
Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze.
Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field.
Antiparasitic activity of two Lavandula essential oils against Giardia duodenalis, Trichomonas vaginalis and Hexamita inflata.
The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal.
Hydrodistillation-headspace solvent microextraction, a new method for analysis of the essential oil components of Lavandula angustifolia Mill.
Antifungal activity of Lavandula angustifolia essential oil against Candida albicans yeast and mycelial form.
The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay.
Antifungal effect of various essential oils against Candida albicans. Potentiation of antifungal action of amphotericin B by essential oil from Thymus vulgaris.
Effect of essential oil concentration on the pH of nutrient and Iso-sensitest broth.
Lavender (Lavandula angustifolia Miller).
Cytotoxicity of lavender oil and its major components to human skin cells.
Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill.
Anti-Aspergillus activities of plant essential oils and their combination effects with ketoconazole or amphotericin B.
Activity of essential oils from Mediterranean Lamiaceae species against food spoilage yeasts.
On-site field sampling and analysis of fragrance from living lavender (Lavandula angustifolia L.) flowers by solid-phase microextraction coupled to gas chromatography and ion-trap mass spectrometry.
GC-MS analysis of essential oils from some Greek aromatic plants and their fungitoxicity on Penicillium digitatum.
Local anaesthetic activity of the essential oil of Lavandula angustifolia.
Studies on the mode of action of the essential oil of lavender (Lavandula angustifolia P. Miller).
Acaricidal agents of natural origin against Psoroptes cuniculi.
Aromatherapy: evidence for sedative effects of the essential oil of lavender after inhalation.
[Neurodepressive effects of the essential oil of Lavandula angustifolia Mill].

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
Export Tariff Code:	3301.23.0000
MedlinePlusSupp:	View
Typical G.C.
Wikipedia:	View
FAO:	BASIC PRINCIPLES OF STEAM DISTILLATION

PhysChem Properties

Material listed in food chemical codex	No
Specific gravity	@ 25 °C
Pounds per Gallon	7.298 to 7.422
Refractive Index	1.457 to 1.464 @ 20 °C
Flash Point TCC Value	83.33 °C TCC
Solubility
alcohol	Yes
water, 20.12 mg/L @ 25 °C (est)	Yes
water	No

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 4250 mg/kg Food and Cosmetics Toxicology. Vol. 14, Pg. 449, 1976. intraperitoneal-rat LD50 540 mg/kg Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite. Vol. 15, Pg. 149, 1973. intraperitoneal-mouse LD50 640 mg/kg Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite. Vol. 15, Pg. 149, 1973.
Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 14, Pg. 451, 1976. skin-guinea pig LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 14, Pg. 449, 1976.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA fragrance material specification:
	Linalool and natural products known to be rich in linalool, such as bois de rose, coriander or ho wood oil, should only be used when the level of peroxides is kept to the lowest practical level. It is recommended to add antioxidants at the time of production of the raw material. The addition of 0.1% BHT or alpha-tocopherol for example has shown great efficiency. The maximum peroxide level for products in use should be 20 mmol/l.
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
coumarin	Max. Found:
geraniol	Max. Found:
7-methoxycoumarin	Max. Found: 0.01 % and Reason: Sentitization / Photo Sensitization
1-octen-3-yl acetate	Max. Found: 0.9 % and Reason: Sensitization
Recommendation for lavender oil greece usage levels up to:
	8.0000 % in the fragrance concentrate.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
		average usual ppm	average maximum ppm
baked goods:		-	8.30000
beverages(nonalcoholic):		-	2.90000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	220.00000
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	7.80000
fruit ices:		-	7.80000
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	5.50000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

EPI System: View

ClinicalTrials.gov:search

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):8000-28-0

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

lavandula angustifolia l. herb oil

Chemidplus:0008000280

RTECS:OF6110000 for cas# 8000-28-0