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Essential oils, rosemary

General Material Information

Trival Name Essential oils, rosemary
Short Description essential oil obtained from the flowering tops and leaves of the rosemary, rosmarinus officinalis l., lamiaceae france
CAS Number 8000-25-7
FDA UNII Search
COE Number 406
FEMA Number 2992
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 8000-25-7 ; ROSEMARY, OIL (ROSEMARINUS OFFICINALIS L.)
Applications
  • flavor and fragrance agents
Synonyms
  • essential oil obtained from the flowering tops and leaves of the rosemary, rosmarinus officinalis l., lamiaceae france
  • rosemary EO
  • rosemary oil camphor organic
  • rosemary oil france
  • rosmarinus officinalis leaf oil france
  • rosmarinus officinalis l. leaf oil
  • Rosemary oil
  • Oils, rosemary
  • Oils, essential, rosemary
  • Essential oils, rosemary
  • Rosamarinus oil
  • Rosmarinus officinalis oil
  • Rosemary leaf oil
  • Essential rosemary oil
  • Rosmarinus officinalis leaf oils
  • Rosemary essential oils
  • Rosmarinus officinalis essential oils
  • Rosmarinus officinalis essential oil
  • Mamorekku RUH 21
  • Hexacide OS
  • Rosemary Liq. E
  • Extrapone Rosemary
  • Extrapone Rosemary P
  • Rosemary needle oil
  • Oleum Rosamarinii
  • Guardian 201
  • R 40
  • Rosmarinus oil

Occurrences

rosemary

Organoleptic Properties

Odor Type: Herbal
Odor strength medium
Substantivity 4 hour(s) at 100.00 %
General comment At 100.00 %. herbal rosemary
Flavor Type: Herbal
General comment Rosemary

Potential Uses

Odor purposes Aldehydic , Alpine bouquet , Amber , Balsam , Cedar , Cologne , Colonia , Eucalyptus oil replacer , Fern , Fir needle oil replacer , Florida soap , Herbal , Lavender , Lavender flower , Mint , Musk , Oriental , Pennyroyal , Rosemary , Spring rain , Thyme oil white replacer , Windsor soap , Woody , Yew
Flavoring purposes Lavender flower , Pennyroyal
Other purposes Hungery water
Cosmetic purposes Fragrance , Skin conditioning

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

rosmarinus officinalis l. leaf oil
Canada Domestic Sub. List:8000-25-7
Pubchem (sid):135307489
Publications by PubMed
Rosmarinus officinalis L. extract and some of its active ingredients as potential emulsion stabilizers: a new approach to the formation of multiple (W/O/W) emulsion.
The influence of purge times on the yields of essential oil components extracted from plants by pressurized liquid extraction.
Chemical composition of Rosmarinus and Lavandula essential oils and their insecticidal effects on Orgyia trigotephras (Lepidoptera, Lymantriidae).
Transdermal absorption enhancing effect of the essential oil of Rosmarinus officinalis on percutaneous absorption of Na diclofenac from topical gel.
Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial.
Comparative and synergistic activity of Rosmarinus officinalis L. essential oil constituents against the larvae and an ovarian cell line of the cabbage looper, Trichoplusia ni (Lepidoptera: Noctuidae).
Study of quantitative and qualitative variations in essential oils of Sicilian Rosmarinus officinalis L.
Antimicrobial and antioxidant activities and chemical characterization of essential oils of Thymusvulgaris, Rosmarinus officinalis, and Origanum majorana from northeastern México.
Enhancing stability of essential oils by microencapsulation for preservation of button mushroom during postharvest.
In vitro susceptibility of Brazilian Pythium insidiosum isolates to essential oils of some Lamiaceae family species.
Effect of rosemary (Rosmarinus officinalis) extracts on the oxidative stability and sensory acceptability of soybean oil.
Active monoterpene ketones isolated from Rosmarinus officinalis with fumigant and contact action against Tyrophagus putrescentiae (Schrank).
In vitro biological evaluation of eight different essential oils against Trypanosoma cruzi, with emphasis on Cinnamomum verum essential oil.
Protective Effect of Lavandula stoechas and Rosmarinus officinalis essential oils against reproductive damage and oxidative stress in alloxan-induced diabetic rats.
Effect of bioclimatic area on the composition and bioactivity of Tunisian Rosmarinus officinalis essential oils.
Dairy matrix effect on the transference of rosemary (Rosmarinus officinalis) essential oil compounds during cheese making.
Effects of Rosmarinus officinalis essential oil on germ tube formation by Candida albicans isolated from denture wearers.
Antifungal activity and inhibition of fumonisin production by Rosmarinus officinalis L. essential oil in Fusarium verticillioides (Sacc.) Nirenberg.
Oxidative stress modulation by Rosmarinus officinalis in creosote-induced hepatotoxicity.
Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential.
Assessment of antioxidative, chelating, and DNA-protective effects of selected essential oil components (eugenol, carvacrol, thymol, borneol, eucalyptol) of plants and intact Rosmarinus officinalis oil.
Microwave-assisted hydrodistillation of essential oil from rosemary.
Antibacterial activity against Clostridium genus and antiradical activity of the essential oils from different origin.
Effects of Rosmarinus officinalis on the survivability of random-patterned skin flaps: an experimental study.
Combined effects of gamma-irradiation and modified atmosphere packaging on quality of some spices.
Secondary metabolites isolation in natural products chemistry: comparison of two semipreparative chromatographic techniques (high pressure liquid chromatography and high performance thin-layer chromatography).
Solvent-free microwave extraction of essential oil from aromatic herbs: from laboratory to pilot and industrial scale.
Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy.
Effectiveness of Rosmarinus officinalis essential oil as antihypotensive agent in primary hypotensive patients and its influence on health-related quality of life.
Microbiological quality and other characteristics of refrigerated chicken meat in contact with cellulose acetate-based film incorporated with rosemary essential oil.
The potential of use basil and rosemary essential oils as effective antibacterial agents.
Effects of inhaled rosemary oil on subjective feelings and activities of the nervous system.
Increased seizure latency and decreased severity of pentylenetetrazol-induced seizures in mice after essential oil administration.
Biogenic amines as freshness index of meat wrapped in a new active packaging system formulated with essential oils of Rosmarinus officinalis.
Effect of the dietary supplementation of essential oils from rosemary and artemisia on muscle fatty acids and volatile compound profiles in Barbarine lambs.
Larvicidal activity of essential extract of Rosmarinus officinalis against Culex quinquefasciatus.
The Antibacterial Activity of Selected Labiatae (Lamiaceae) Essential Oils against Brucella melitensis.
Efficacy of plant essential oils on postharvest control of rots caused by fungi on different stone fruits in vivo.
Transfer of metals and metalloids from soil to shoots in wild rosemary (Rosmarinus officinalis L.) growing on a former lead smelter site: human exposure risk.
In vitro and in vivo antifungal activity of some essential oils against feline isolates of Microsporum canis.
Seasonal variations in the composition of the essential oils of rosemary (Rosmarinus officinalis, Lamiaceae).
A herbal antifungal formulation of Thymus serpillum, Origanum vulgare and Rosmarinus officinalis for treating ovine dermatophytosis due to Trichophyton mentagrophytes.
An in-depth review on the medicinal flora Rosmarinus officinalis (Lamiaceae).
Supercritical carbon dioxide extraction of antioxidants from rosemary (Rosmarinus officinalis) leaves for use in edible vegetable oils.
Rosmarinus officinalis L. essential oil and its majority compound 1,8-cineole at sublethal amounts induce no direct and cross protection in Staphylococcus aureus ATCC 6538.
Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L.
Antioxidant capacity and inhibitory effect of grape seed and rosemary extract in marinades on the formation of heterocyclic amines in fried beef patties.
Degradation study of carnosic acid, carnosol, rosmarinic acid, and rosemary extract (Rosmarinus officinalis L.) assessed using HPLC.
The effects of thyme (Thymus vulgaris) and rosemary (Rosmarinus officinalis) essential oils on Brochothrix thermosphacta and on the shelf life of beef packaged in high-oxygen modified atmosphere.
Rosmarinus officinalis L. essential oil and the related compound 1,8-cineole do not induce direct or cross-protection in Listeria monocytogenes ATCC 7644 cultivated in meat broth.
Environment-related variations of the composition of the essential oils of rosemary (Rosmarinus officinalis L.) in the Balkan Penninsula.
Comparative molecular docking analysis of essential oil constituents as elastase inhibitors.
Composition and biological activity of essential oils against Metopolophium dirhodum (Hemiptera: Aphididae) cereal crop pest.
Hybrid magnetite nanoparticles/Rosmarinus officinalis essential oil nanobiosystem with antibiofilm activity.
Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components.
Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats.
Application of ionic liquids based microwave-assisted simultaneous extraction of carnosic acid, rosmarinic acid and essential oil from Rosmarinus officinalis.
Inhibitory activity of Asian spices on heterocyclic amines formation in cooked beef patties.
Acaricidal effect of essential oils from Lippia graveolens (Lamiales: Verbenaceae), Rosmarinus officinalis (Lamiales: Lamiaceae), and Allium sativum (Liliales: Liliaceae) against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).
Antioxidant and antigenotoxic effects of rosemary (Rosmarinus officinalis L.) extracts in Salmonella typhimurium TA98 and HepG2 cells.
Larvicidal and repellent properties of some essential oils against Culex tritaeniorhynchus Giles and Anopheles subpictus Grassi (Diptera: Culicidae).
Chemical composition and antimicrobial activity of essential oils of Thymus algeriensis, Eucalyptus globulus and Rosmarinus officinalis from Morocco.
Evaluation of antileishmanial, cytotoxic and antioxidant activities of essential oils extracted from plants issued from the leishmaniasis-endemic region of Sned (Tunisia).
Rosmarinus officinalis L. essential oil inhibits in vivo and in vitro leukocyte migration.
Effect of distillation waste water and plant hormones on spearmint growth and composition.
Control of the myiasis-producing fly, Lucilia sericata, with Egyptian essential oils.
Investigation of the volatile fraction of rosemary infusion extracts.
Antibacterial activity of the essential oil from Rosmarinus officinalis and its major components against oral pathogens.
Comparative larvicidal activity of essential oils from three medicinal plants against Aedes aegypti L.
Genotoxicity and mutagenicity of Rosmarinus officinalis (Labiatae) essential oil in mammalian cells in vivo.
Rosmarinus officinalis essential oil: antiproliferative, antioxidant and antibacterial activities.
In vitro and in vivo antifungal activities of the essential oils of various plants against tomato grey mould disease agent Botrytis cinerea.
Essential oils composition in two Rosmarinus officinalis L. varieties and incidence for antimicrobial and antioxidant activities.
Essential oil composition and larvicidal activity of six Mediterranean aromatic plants against the mosquito Aedes albopictus (Diptera: Culicidae).
Biodegradable gelatin-chitosan films incorporated with essential oils as antimicrobial agents for fish preservation.
Chemical composition and antioxidant and anti-Listeria activities of essential oils obtained from some Egyptian plants.
Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice.
Bioactivity of Rosmarinus officinalis essential oils against Apis mellifera, Varroa destructor and Paenibacillus larvae related to the drying treatment of the plant material.
Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats.
Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity.
Testing and enhancing the in vitro bioaccessibility and bioavailability of Rosmarinus officinalis extracts with a high level of antioxidant abietanes.
In vitro antimicrobial and antioxidant activity of commercial rosemary extract formulations.
Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats.
The antimicrobial activity of four commercial essential oils in combination with conventional antimicrobials.
Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts.
Anti-inflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models.
In vitro activity of essential oils extracted from plants used as spices against fluconazole-resistant and fluconazole-susceptible Candida spp.
Antioxidant activities of rosemary (Rosmarinus Officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol.
Phytotherapeutic prevention of dental biofilm formation.
Chemical composition and antifungal activity of rosemary (Rosmarinus officinalis L.) oil from Turkey.
Variation of the chemical profile and antioxidant behavior of Rosmarinus officinalis L. and Salvia fruticosa Miller grown in Greece.
Effect of some essential oils on rheological properties of wheat flour dough.
Antioxidative activity of Rosmarinus officinalis L. essential oil compared to its main components.
Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes.
Antibacterial efficiency of Spanish Satureja montana essential oil against Listeria monocytogenes among natural flora in minced pork.
Antimycotoxigenic characteristics of Rosmarinus officinalis and Trachyspermum copticum L. essential oils.
Investigation of antibacterial activity of rosemary essential oil against Propionibacterium acnes with atomic force microscopy.
Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils.
Relative characterization of rosemary samples according to their geographical origins using microwave-accelerated distillation, solid-phase microextraction and Kohonen self-organizing maps.
Antimicrobial activity of clove and rosemary essential oils alone and in combination.
[The virtue of that precious balsam...: approach to Don Quixote from the psychopharmacological perspective].
Characterization of topical antiinflammatory compounds in Rosmarinus officinalis L.
Efficacy and persistence of rosemary oil as an acaricide against twospotted spider mite (Acari: Tetranychidae) on greenhouse tomato.
The psychopharmacology of European herbs with cognition-enhancing properties.
Effect of Rosmarinus officinalis in modulating 7,12-dimethylbenz(a)anthracene induced skin tumorigenesis in mice.
Influence of rosemary (Rosmarinus officinalis, L.) on plant sterol oxidation in extra virgin olive oil.
Liquid chromatograpic-mass spectrometric analysis of phenolics and free radical scavenging activity of rosemary extract from different raw material.
Comparative toxicity of Rosmarinus officinalis L. essential oil and blends of its major constituents against Tetranychus urticae Koch (Acari: Tetranychidae) on two different host plants.
Antimicrobial activities of the essential oils of various plants against tomato late blight disease agent Phytophthora infestans.
[Influence of extraction methods on the composition of essential oils].
Insecticidal, repellent and oviposition-deterrent activity of selected essential oils against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus.
Composition and insect attracting activity of the essential oil of Rosmarinus officinalis.
Chemical composition and antimicrobial activity of Rosmarinus officinalis L. essential oil obtained via supercritical fluid extraction.
Antifungal effect of various essential oils against Candida albicans. Potentiation of antifungal action of amphotericin B by essential oil from Thymus vulgaris.
Antiviral activity of medicinal plants of Nilgiris.
chemical composition, plant genetic differences, antimicrobial and antifungal activity investigation of the essential oil of Rosmarinus officinalis L.
Antioxidant activities of rosemary, sage, and sumac extracts and their combinations on stability of natural peanut oil.
Essential oils from Mediterranean lamiaceae as weed germination inhibitors.
Essential oil formulations useful as a new tool for insect pest control.
Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes.
Anti-Aspergillus activities of plant essential oils and their combination effects with ketoconazole or amphotericin B.
Main agronomic-productive characteristics of two ecotypes of Rosmarinus officinalis L. and chemical composition of their essential oils.
SPME determination of volatile aldehydes for evaluation of in-vitro antioxidant activity.
GC-MS analysis of essential oils from some Greek aromatic plants and their fungitoxicity on Penicillium digitatum.
Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis.
Comparative evaluation of the antimicrobial activities of essential oils of Artemisia afra, Pteronia incana and Rosmarinus officinalis on selected bacteria and yeast strains.
GC evaluation of flavour compounds sorption from water solutions by corn starch cryotextures obtained by freezing.
Hyperglycemic and insulin release inhibitory effects of Rosmarinus officinalis.
Use of a programmed temperature vaporizer for off-line SFE/GC analysis in food composition studies.
Relaxant effect of the volatile oil of Rosmarinus officinalis on tracheal smooth muscle.
In Vitro Production of Essential Oil from Proliferating Shoots of Rosmarinus officinalis1.
Quantitative variations of some components of the foliage volatile oil of Rosmarinus officinalis L. in the spring. Terpenes and related compounds. XIX.
[Composition of etheric oil in the leaves of Rosmarinus officinalis L. 1. Monoterpenchydrocarbons. Terpenes and related materials VI].
Comparison of rumen microbial inhibition resulting from various essential oils isolated from relatively unpalatable plant species.

Other Information

FDA Substances Added to Food (formerly EAFUS):View
Export Tariff Code:3301.29.6000
Typical G.C.
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION

PhysChem Properties

Material listed in food chemical codex No
Specific gravity @ 25 °C
Pounds per Gallon 7.489 to 7.614
Refractive Index 1.457 to 1.475 @ 20 °C
Flash Point TCC Value 40 °C TCC
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
water, 1186 mg/L @ 25 °C (est) Yes
water No

Safety Information

Safety information

European information :
Most important hazard(s):
Xn N - Harmful, Dangerous for the environment.
R 10 - Flammable.
R 22 - Harmful if swallowed.
R 36/38 - Irritating to skin and eyes.
R 43 - May cause sensitisation by skin contact.
R 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R 65 - Harmful: may cause lung damage if swallowed.
R 68 - Possible risk of irreversible effects.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 24 - Avoid contact with skin.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
S 62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 977, 1974.

Dermal Toxicity:
skin-rabbit LD50 > 10000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 977, 1974.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for rosemary oil france usage levels up to:
10.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -6.30000
beverages(nonalcoholic): -3.60000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -2.90000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.500004.00000
fruit ices: 0.500004.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -7.50000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -40.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

EPI System: View
Daily Med:search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8000-25-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
rosmarinus officinalis l. leaf oil
Chemidplus:0008000257
RTECS:VL0445000 for cas# 8000-25-7