cimicifuga racemosa root distillates

General Material Information

Trivial Name	cimicifuga racemosa root distillates
Synonyms	actaea racemosa root distillates bugbane root distillates black cohosh root distillates black snakeroot root distillates

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Literature & References

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Publications by PubMed
Effect of Isopropanolic Cimicifuga racemosa Extract on Uterine Fibroids in Comparison with Tibolone among Patients of a Recent Randomized, Double Blind, Parallel-Controlled Study in Chinese Women with Menopausal Symptoms.
Mechanism of hepatotoxicity due to black cohosh (Cimicifuga racemosa): Histological, immunohistochemical and electron microscopy analysis of two liver biopsies with clinical correlation.
Evaluation of the botanical origin of black cohosh products by genetic and chemical analyses.
Herbalists' perception of risks involving commonly sold medicinal plants in Italy.
Efficacy of black cohosh (Cimicifuga racemosa L.) in treating early symptoms of menopause: a randomized clinical trial.
Effects of remifemin treatment on bone integrity and remodeling in rats with ovariectomy-induced osteoporosis.
Systems approaches to unraveling plant metabolism: identifying biosynthetic genes of secondary metabolic pathways.
Phytochemical identity and stability of herbal products: challenges for clinical research.
Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints.
The value of complementary and alternative medicine in the treatment of climacteric symptoms: results of a survey among German gynecologists.
Efficacy of black cohosh (Cimicifuga racemosa) medicines for treatment of menopausal symptoms - comments on major statements of the Cochrane Collaboration report 2012 "black cohosh (Cimicifuga spp.) for menopausal symptoms (review)".
Attenuation of nucleoside and anti-cancer nucleoside analog drug uptake in prostate cancer cells by Cimicifuga racemosa extract BNO-1055.
Effects of black cohosh on the plasminogen activator system in vascular smooth muscle cells.
The effect of a Cimicifuga racemosa extracts Ze 450 in the treatment of climacteric complaints--an observational study.
Adverse effects of herbal medicines: an overview of systematic reviews.
The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh (Cimicifuga or Actaea racemosa).
Black cohosh and breast cancer: a systematic review.
Dose-Dependent Effects of the Cimicifuga racemosa Extract Ze 450 in the Treatment of Climacteric Complaints: A Randomized, Placebo-Controlled Study.
Estrogen receptor mediated effects of Cimicifuga extracts on human breast cancer cells.
Black cohosh (Cimicifuga spp.) for menopausal symptoms.
Oral administration of Cimicifuga racemosa extract attenuates psychological and physiological stress responses.
Osteoprotective effects of Cimicifuga racemosa and its triterpene-saponins are responsible for reduction of bone marrow fat.
Cimicifuga racemosa impairs fatty acid β-oxidation and induces oxidative stress in livers of ovariectomized rats with renovascular hypertension.
Effects of black cohosh and estrogen on the hypothalamic nuclei of ovariectomized rats at different temperatures.
Cimicifuga racemosa and its triterpene-saponins prevent the Metabolic Syndrome and deterioration of cartilage in the knee joint of ovariectomized rats by similar mechanisms.
Oral administration of Cimicifuga racemosa extract affects immobilization stress-induced changes in murine cerebral monoamine metabolism.
One new and six known triterpene xylosides from Cimicifuga racemosa: FT-IR, Raman and NMR studies and DFT calculations.
Oral administration of Cimicifuga racemosa extract attenuates immobilization stress-induced reactions.
Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a systematic review.
Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity.
Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).
Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice.
Black cohosh (Cimicifuga racemosa) relaxes the isolated rat thoracic aorta through endothelium-dependent and -independent mechanisms.
Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).
Effects of an isopropanolic-aqueous black cohosh extract on central body temperature of ovariectomized rats.
Deoxyactein stimulates osteoblast function and inhibits bone-resorbing mediators in MC3T3-E1 cells.
In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4.
Black Cohosh Hepatic Safety: Follow-Up of 107 Patients Consuming a Special Cimicifuga racemosa rhizome Herbal Extract and Review of Literature.
Phytochemical fingerprinting to thwart black cohosh adulteration: a 15 Actaea species analysis.
Metabolic profiling of Actaea species extracts using high performance liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.
Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles.
Black cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints - a prospective observational study.
Phytotherapy as alternative to hormone replacement therapy.
Gene identification in black cohosh (Actaea racemosa L.): expressed sequence tag profiling and genetic screening yields candidate genes for production of bioactive secondary metabolites.
Bradycardia in a patient taking black cohosh.
Medicinal plants as alternative treatments for female sexual dysfunction: utopian vision or possible treatment in climacteric women?
The Cimicifuga racemosa special extract BNO 1055 prevents hot flashes in ovariectomized rats.
Black cohosh (black snakeroot, Cimicifuga racemosa (L.) Nutt., Actaea racemosa L.).
Absence of positive effect of black cohosh (Cimicifuga racemosa) on fracture healing in osteopenic rodent model.
Effect of exercise and Cimicifuga racemosa (CR BNO 1055) on bone mineral density, 10-year coronary heart disease risk, and menopausal complaints: the randomized controlled Training and Cimicifuga racemosa Erlangen (TRACE) study.
Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh.
Effects of black cohosh (Cimicifuga racemosa) and estrogen on metaphyseal fracture healing in the early stage of osteoporosis in ovariectomized rats.
[Efficacy and safety of remifemin compared to tibolone for controlling of perimenopausal symptoms].
Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood.
Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol--a randomized trial.
Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages.
Randomized, double-blind, placebo-controlled trial of Cimicifuga racemosa (black cohosh) in women with anxiety disorder due to menopause.
Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa (Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages.
Influence of black cohosh (Cimicifuga racemosa) use by postmenopausal women on total hepatic perfusion and liver functions.
A case of hepatitis associated with long-term use of Cimicifuga racemosa.
Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?
Effects of estradiol benzoate, raloxifen and an ethanolic extract of Cimicifuga racemosa in nonclassical estrogen regulated organs of ovariectomized rats.
Black cohosh hepatotoxicity: quantitative causality evaluation in nine suspected cases.
No effect of Cimicifuga racemosa extract on serum interleukin-6 levels and prostacyclin production by human endothelial cells.
Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).
Rapid high-performance thin-layer chromatographic method for detection of 5% adulteration of black cohosh with Cimicifuga foetida, C. heracleifolia, C. dahurica, or C. americana.
Cimicifuga racemosa treatment and health related quality of life in post-menopausal Spanish women.
Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.
Black cohosh for the management of menopausal symptoms : a systematic review of clinical trials.
Effects of Trifolium pratense and Cimicifuga racemosa on the endometrium of Wistar rats.
A randomized placebo-controlled trial on the effectiveness of an herbal formula to alleviate menopausal vasomotor symptoms.
In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.
Black cohosh (Cimicifuga racemosa): a systematic review of adverse events.
Stability evaluation of selected polyphenols and triterpene glycosides in black cohosh.
Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats.
New approaches in analyzing the pharmacological properties of herbal extracts.
[Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials].
Black cohosh (Cimicifuga racemosa) for menopausal symptoms: a systematic review of its efficacy.
Ethanolic extract of Actaea racemosa (black cohosh) potentiates bone nodule formation in MC3T3-E1 preosteoblast cells.
Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line.
Detection of Actaea racemosa adulteration by thin-layer chromatography and combined thin-layer chromatography-bioluminescence.
High-content screening and mechanism-based evaluation of estrogenic botanical extracts.
Effects of Cimicifuga racemosa extract on liver morphology and hepatic function indices.
Adding phytoestrogens to clomiphene induction in unexplained infertility patients--a randomized trial.
United States Pharmacopeia review of the black cohosh case reports of hepatotoxicity.
The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use.
Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.
Hepatic effects of Cimicifuga racemosa extract in vivo and in vitro.
Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7.
Estrogen-like effect of a Cimicifuga racemosa extract sub-fraction as assessed by in vivo, ex vivo and in vitro assays.
A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNFalpha signaling pathways.
Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients.
Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone.
Chlorination diversifies Cimicifuga racemosa triterpene glycosides.
Black cohosh (Actaea racemosa, syn. Cimicifuga racemosa): the queen of the female pharmacopeia.
Induction of labor with homeopathy: a case report.
Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms.
Isopropanolic black cohosh extract and recurrence-free survival after breast cancer.
Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: a comparison using a sequential three-solvent extraction process.
Petasiphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaP.
[Effectiveness and safety of the treatment of menopausal syndrome with Cimicifuga racemosa dry extract].
Cutaneous pseudolymphoma induced by Cimicifuga racemosa.
Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor.
Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric-related symptoms in postmenopausal women: a double-blind, randomized, placebo-controlled trial.
[Herbal medicine in womens' life cycle].
Safety and efficacy of black cohosh (Cimicifuga racemosa) during pregnancy and lactation.
First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055.
Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1.
Inhibitory effects of a black cohosh (Cimicifuga racemosa) extract on prostate cancer.
Neocimicigenosides A and B, cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their effects on CRF-stimulated ACTH secretion from AtT-20 cells.
Improvement in the appearance of wrinkles with topical transforming growth factor beta(1) and l-ascorbic acid.
Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study.
Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry.
The growth inhibitory activity of the Cimicifuga racemosa extract Ze 450 is mediated through estrogen and progesterone receptors-independent pathways.
A review of non-hormonal options for the relief of menopausal symptoms.
Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products.
Black cohosh and St. John's wort for climacteric complaints: a randomized trial.
Muscle damage induced by black cohosh (Cimicifuga racemosa).
Isopropanolic extract of black cohosh stimulates osteoprotegerin production by human osteoblasts.
Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans.
No estrogen-like effects of an isopropanolic extract of Rhizoma Cimicifugae racemosae on uterus and vena cava of rats after 17 day treatment.
Triterpenoid glycoside from Cimicifuga racemosa.
Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.
Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial.
Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study.
The effects of remifemin on subjective symptoms of menopause.
Phenolic esters from the rhizomes of Cimicifuga racemosa do not cause proliferation effects in MCF-7 cells.
Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol.
Isolation of CYP3A4 Inhibitors from the Black Cohosh (Cimicifuga racemosa).
Effects of estradiol-17beta, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats.
In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes.
Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms.
Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP.
LC/TIS-MS fingerprint profiling of Cimicifuga species and analysis of 23-Epi-26-deoxyactein in Cimicifuga racemosa commercial products.
Synthesis of cimiracemate B, a phenylpropanoid found in Cimicifuga racemosa.
Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells.
The safety of black cohosh (Actaea racemosa, Cimicifuga racemosa).
In vivo effects of black cohosh and genistein on estrogenic activity and lipid peroxidation in Japanese Medaka (Oryzias latipes).
Inhibition of mast cell-dependent allergy reaction by extract of black cohosh (Cimicifuga racemosa).
Methods of phytochemical standardisation of rhizoma Cimicifugae racemosae.
Phytoestrogens in botanical dietary supplements: implications for cancer.
Cimicifuga racemosa extract inhibits proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of apoptosis.
Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.
Phytoestrogen cimicifugoside-mediated inhibition of catecholamine secretion by blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin cells.
Effects of an isopropanolic extract of Cimicifuga racemosa on urinary crosslinks and other parameters of bone quality in an ovariectomized rat model of osteoporosis.
Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta.
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.
Black cohosh.
In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh).
Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief.
Pharmacological effects of Cimicifuga racemosa.
Hepatotoxicity from Cimicifuga racemosa? Recent Australian case report not sufficiently substantiated.
Cimicifuga racemosa. Monograph.
Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry.
Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy.
Stimulation of alkaline phosphatase activity in Ishikawa cells induced by various phytoestrogens and synthetic estrogens.
Phytoestrogens for hormone replacement therapy?
Estrogenic Effects of Cimicifuga racemosa (Black Cohosh) in Mice and on Estrogen Receptors in MCF-7 Cells.
The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers.
Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer.
Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity.
Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus.
In vitro effects of the Cimicifuga racemosa extract BNO 1055.
Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?
Cultivation of Cimicifuga racemosa (L.) nuttal and quality of CR extract BNO 1055.
A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.
Black cohosh: an alternative therapy for menopause?
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.
Influence of Cimicifuga racemosa on the proliferation of estrogen receptor-positive human breast cancer cells.
Cimiracemosides I-P, new 9,19-cyclolanostane triterpene glycosides from Cimicifuga racemosa.
In vitro plant regeneration from leaf-derived callus of Cimicifuga racemosa.
Phytoestrogens: a viable option?
Cimiracemates A-D, phenylpropanoid esters from the rhizomes of Cimicifuga racemosa.
[Pharmacologic and clinical studies using Cimicifuga racemosa in climacteric complaints].
Analysis of thirteen populations of black cohosh for formononetin.
Cimicifuga racemosa: a systematic review of its clinical efficacy.
Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract.
Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay.
Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein.
Antiestrogenic activities of Cimicifuga racemosa extracts.
Cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their cytotoxic activities.
Actaeaepoxide 3-O-beta-D-xylopyranoside, a new cycloartane glycoside from the rhizomes of Actaea racemosa (Cimicifuga racemosa).
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.
Black cohosh: efficacy, safety, and use in clinical and preclinical applications.
[Estrogenicity of black cohosh (Cimicifuga racemosa) and its effect on estrogen receptor level in human breast cancer MCF-7 cells].
A new cyclolanostanol arabinoside from the rhizome of Cimicifuga racemosa.
Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa.
Direct analysis and identification of triterpene glycosides by LC/MS in black cohosh, Cimicifuga racemosa, and in several commercially available black cohosh products.
Triterpene glycosides from Cimicifuga racemosa.
Cimiracemoside a: A new cyclolanostanol xyloside from the rhizome of Cimicifuga racemosa.
Fukiic and piscidic acid esters from the rhizome of Cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid.
Hormone-modulating herbs: implications for women's health.
Black cohosh: Cimicifuga racemosa.
A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause.
Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders.
Flavones in extracts of Cimicifuga racemosa.
Cimicifuga and Melbrosia lack oestrogenic effects in mice and rats.
Effects of extracts from Cimicifuga racemosa on gonadotropin release in menopausal women and ovariectomized rats.
[Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa].
Studies on the endocrine effects of the contents of Cimicifuga racemosa 2. In vitro binding of compounds to estrogen receptors.
[The endocrine effects of constituents of Cimicifuga racemosa. 2. In vitro binding of constituents to estrogen receptors].
Studies on the endocrine effects of the contents of Cimicifuga racemosa:.
[Endocrine effects of constituents of Cimicifuga racemosa. 1. The effect on serum levels of pituitary hormones in ovariectomized rats].
[Contents of Cimicifuga racemosa. 5. 27-desoxyacetylacteol].
[Contents of Cimicifuga racemosa. 3. On the constitution of the rings A, B and C of actein].
[Contents of Cimicifuga racemosa. 2. On the structure of actein].
[THE COMPOSITION OF CIMICIFUGA RACEMOSA. 1. ON THE ISOLATION OF 2 GLYCOSIDES].
[The effects of an extract from Cimicifuga racemosa].
[Cimicifuga racemosa in otology; experimental study].
[Cimicifuga racemosa in gynecology].

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PhysChem Properties

Material listed in food chemical codex

Organoleptic Properties

Flavor Type: Bitter
bitter, spicy, acidic
General comment	Bitter spicy acidic

Occurrences

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic agents
Recommendation for cimicifuga racemosa root distillates usage levels up to:
	not for fragrance use.

Recommendation for cimicifuga racemosa root distillates flavor usage levels up to:
	not for flavor use.

Safety references

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