cinnamomum cassia bark powder

General Material Information

Preferred name	cinnamomum cassia bark powder
Trivial Name	cinnamomum cassia
Short Description	plant material derived from the dried bark of the chinese cinnamon, cinnamomum cassia (l.), lauraceae
CAS Number	8007-80-5
CAS Number	84961-46-6
FEMA Number	2256
ECHA Number	284-635-0
FDA UNII	Search
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
Synonyms	camphorina cassia bark powder cassia bark powder cinnamomum aromaticum bark powder cinnamomum longifolium bark powder cinnamomum medium bark powder cinnamomum nitidum bark powder laurus cassia bark powder persea cassia bark powder plant material derived from the dried bark of the chinese cinnamon, cinnamomum cassia (l.), lauraceae

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Literature & References

	cinnamomum cassia
Canada Domestic Sub. List:	8007-80-5
Pubchem (sid):	135352886
	cinnamomum cassia
Canada Domestic Sub. List:	84961-46-6
Pubchem (sid):	135310975

Publications by PubMed
Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia.
Traditional formula, modern application: chinese medicine formula sini tang improves early ventricular remodeling and cardiac function after myocardial infarction in rats.
Effect of Cinnamomum cassia methanol extract and sildenafil on arginase and sexual function of young male Wistar rats.
Evaluation of the in vitro anti-hyperglycemic effect of Cinnamomum cassia derived phenolic phytochemicals, via carbohydrate hydrolyzing enzyme inhibition.
Interaction of gypsum and the rhizome of Anemarrhena asphodeloides plays an important role in anti-allergic effects of byakkokakeishito in mice.
Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer.
Identification of compounds from the water soluble extract of Cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells.
A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang').
Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling.
Fumigant toxicity of plant essential oils against Camptomyia corticalis (Diptera: Cecidomyiidae).
Antioxidant activity of various parts of Cinnamomum cassia extracted with different extraction methods.
Bioactive A-type proanthocyanidins from Cinnamomum cassia.
Differential antiproliferation effect of 2'-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants.
2'-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation.
Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks.
Platelet anti-aggregation activities of compounds from Cinnamomum cassia.
Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves.
The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.
Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1.
Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential.
Selective stimulation by cinnamaldehyde of progesterone secretion in human adrenal cells.
Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways.
Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase-independent manner.
[Analysis on the chemical compositions of the volatile oil from ultramicro-powder and common grinding powder of Cinnamomum cassia].
Quality assessment of cortex cinnamomi by HPLC chemical fingerprint, principle component analysis and cluster analysis.
Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells.
Nematicidal Activity of Cassia and Cinnamon Oil Compounds and Related Compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae).
Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on the function of osteoblastic MC3T3-E1 cells.
Repellency of Cinnamomum cassia bark compounds and cream containing cassia oil to Aedes aegypti (Diptera: Culicidae) under laboratory and indoor conditions.
In vitro efficacy of 75 essential oils against Aspergillus niger.
Antimicrobial effects of selected plant essential oils on the growth of a Pseudomonas putida strain isolated from meat.
Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia Blume.
Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes.
Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro.
Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography.
Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells.
Inhibition of Trypanosoma cruzi by plant extracts used in Chinese medicine.
Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia.
[Isolation of genomic DNA from Cinnamomum cassia Presl].
Repellency of aromatic medicinal plant extracts and a steam distillate to Aedes aegypti.
Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma.
Antioxidant activity of Cinnamomum cassia.
Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells.
Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat.
[Comparison studies on chemical constituents of essential oil from Ramulus Cinnamomi and Cortex Cinnamomi by GC-MS].
Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase.
Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase.
Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties.
Growth-Inhibiting Effects of Cinnamomum cassia Bark-Derived Materials on Human Intestinal Bacteria.
A survey of some Indian medicinal plants for anti-human immunodeficiency virus (HIV) activity.
Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells.
Insecticidal and fumigant activities of Cinnamomum cassia bark-derived materials against Mechoris ursulus (Coleoptera: attelabidae).
Synthesis and in vitro cytotoxicity of cinnamaldehydes to human solid tumor cells.
Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.
2'-Hydroxycinnamaldehyde from stem bark of Cinnamomum cassia.
Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas.
A reticuloendothelial system-activating arabinoxylan from the bark of Cinnamomum cassia.
Antiulcerogenic compounds isolated from Chinese cinnamon.
Effects of a Chinese herbal medicine, keishi-bukuryo-gan, on the gonadal system of rats.
[Pharmacological studies of Cinnamomum cassia bark. Part I. Effects on the blood and cardiovascular system (author's transl)].

Other Information

FDA Substances Added to Food (formerly EAFUS):	View
FDA Listing of Food Additive Status:	View
MedlinePlusSupp:	View
Wikipedia:	View

Suppliers

Bristol Botanicals	Penta International
Whole Herb	Penta International Corporation

PhysChem Properties

Material listed in food chemical codex

Organoleptic Properties

Odor Type: Spicy
cinnamon, cassia
General comment	At 100.00 %. cinnamon
Flavor Type: Spicy
cinnamon, cassia
General comment	Cinnamon

Occurrences

Potential Uses

Applications	spices other natural seasonings and flavorings
Flavoring purposes	Spice
Cosmetic purposes	Skin conditioning

Safety Information

Safety information

European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 500 mg/kg VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA Pharmacologist. Vol. 3, Pg. 62, 1961. oral-mouse LD50 2670 mg/kg Tokishikoroji Foramu. Toxicology Forum. Vol. 8, Pg. 91, 1985. oral-rat LD50 2800 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 109, 1975.
Dermal Toxicity:
skin-rabbit LD50 320 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 109, 1975.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
spices, other natural seasonings and flavorings
Recommendation for cinnamomum cassia bark powder usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
		average usual ppm	average maximum ppm
baked goods:		-	3000.00000
beverages(nonalcoholic):		-	9.20000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	5.10000
fruit ices:		-	5.10000
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	130.00000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

ClinicalTrials.gov:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):8007-80-5

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

cinnamomum cassia

Chemidplus:0008007805

cinnamomum cassia

Chemidplus:084961466