| Preferred name | propionic acid |
| Trivial Name | Propionic acid |
| Short Description | pseudoacetic acid |
| Formula | C3 H6 O2 |
| CAS Number | 79-09-4 |
| Deleted CAS Number | 1032826-44-0 |
| FEMA Number | 2924 |
| Flavis Number | 8.003 |
| ECHA Number | 201-176-3 |
| FDA UNII | JHU490RVYR |
| Nikkaji Number | J1.963A |
| Beilstein Number | 0506071 |
| MDL | MFCD00002756 |
| COE Number | 3 |
| NMR Predictor | External link |
| JECFA Food Flavoring | 84 propionic acid |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 79-09-4 ; PROPIONIC ACID |
| Synonyms |
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| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
| propanoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 79-09-4 |
| Pubchem (cid): | 1032 |
| Pubchem (sid): | 134971247 |
| Pherobase: | View |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00163 |
| HMDB (The Human Metabolome Database): | HMDB00237 |
| FooDB: | FDB008285 |
| Export Tariff Code: | 2915.50.1000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| FAO: | Propionic acid |
| Formulations/Preparations: •grades: technical, 99.0%; food chemicals codex •trade names: luprosil; proxoin; tenox p. | |
| Material listed in food chemical codex | Yes |
| Molecular weight | 74.079223632812 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 8.238 to 8.321 |
| Refractive Index | 1.385 to 1.389 @ 20 °C |
| Melting Point | -24 to -23°C @ 760 mm Hg |
| Boiling Point | 140 to 141°C @ 760 mm Hg |
| Boiling Point | 70 to 71°C @ 50 mm Hg |
| Vapor Pressure | 4.227 mmHg @ 25 °C |
| Vapor Density | 2.56 |
| Flash Point TCC Value | 53.89 °C TCC |
| logP (o/w) | 0.33 |
| Shelf life | 12 months (or longer if stored properly.) |
| Storage notes | Refrigerate in tightly sealed containers. |
| Solubility | |
| alcohol | Yes |
| water, 1.736e+005 mg/L @ 25 °C (est) | Yes |
| oils | Yes |
| propylene glycol | Yes |
| water, 1.00E+06 mg/L @ 25 °C (exp) | Yes |
| Odor Type: Acidic | |
| pungent, acidic, cheesy, vinegar, dairy | |
| Odor strength | high , recommend smelling in a 0.10 % solution or less |
| Substantivity | 8 hour(s) at 100.00 % |
| Luebke, William tgsc, (1989) | At 0.10 % in propylene glycol. pungent acidic cheesy vinegar |
| Mosciano, Gerard P&F 15, No. 6, 35, (1990) | Pungent acidic and dairy-like |
| VCF-online | Acid, fat, pungent, rancid, raspberry, silage, soy |
| Flavor Type: Acidic | |
| acidic, dairy, fruity | |
| Mosciano, Gerard P&F 15, No. 6, 35, (1990) | At 60.00 ppm. Acidic, dairy with a pronounced fruity lift |
| General comment | Pungent acidic cheesy |
| (data available) |
| Applications | |
| Odor purposes | Cajeput , Crabapple , Lavender |
| Flavoring purposes | Bread , Butter , Cajeput , Cheese , Coffee , Cognac , Milk |
| Cosmetic purposes | Preservatives |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| C - Corrosive. | |
| R 10 - Flammable. R 34 - Causes burns. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 2600 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 110, 1974. intravenous-mouse LD50 625 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmacologica et Toxicologica. Vol. 18, Pg. 141, 1961. intravenous-rabbit LD50 1320 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 110, 1974. oral-mammal (species unspecified) LD50 1640 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974. unreported-mouse LD50 1370 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(3), Pg. 96, 1970. unreported-rabbit LD50 1900 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(3), Pg. 96, 1970. intravenous-rabbit LDLo 1320 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 110, 1974. parenteral-rat LD50 3500 mg/kg Defense des Vegetaux. Vol. 26, Pg. 5, 1972. unreported-rat LD50 1510 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(3), Pg. 96, 1970. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 500 ul/kg American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| sanitizing agents for food processing equipment, flavoring agents | |||
| Recommendation for propionic acid usage levels up to: | |||
| not for fragrance use. | |||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3. Update in publication number(s): 29 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 200.00000 | 500.00000 | |
| beverages(nonalcoholic): | 50.00000 | 500.00000 | |
| beverages(alcoholic): | 0.01000 | 0.01000 | |
| breakfast cereal: | 50.00000 | 500.00000 | |
| cheese: | 100.00000 | 600.00000 | |
| chewing gum: | 100.00000 | 300.00000 | |
| condiments / relishes: | 100.00000 | 500.00000 | |
| confectionery froastings: | - | - | |
| egg products: | 50.00000 | 500.00000 | |
| fats / oils: | 50.00000 | 500.00000 | |
| fish products: | 50.00000 | 500.00000 | |
| frozen dairy: | 50.00000 | 500.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | 100.00000 | 500.00000 | |
| hard candy: | 14.00000 | 14.00000 | |
| imitation dairy: | 50.00000 | 500.00000 | |
| instant coffee / tea: | 100.00000 | 500.00000 | |
| jams / jellies: | - | - | |
| meat products: | 50.00000 | 500.00000 | |
| milk products: | 50.00000 | 500.00000 | |
| nut products: | 50.00000 | 500.00000 | |
| other grains: | - | - | |
| poultry: | 50.00000 | 500.00000 | |
| processed fruits: | - | - | |
| processed vegetables: | 50.00000 | 500.00000 | |
| reconstituted vegetables: | 50.00000 | 500.00000 | |
| seasonings / flavors: | 50.00000 | 500.00000 | |
| snack foods: | 50.00000 | 500.00000 | |
| soft candy: | 0.01000 | 0.01000 | |
| soups: | 50.00000 | 500.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 18 (FGE.18): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical group 6 View page or View pdf |
| Flavouring Group Evaluation 18, Revision 1 (FGE. 18 Rev1)[1] : Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8 View page or View pdf |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 View page or View pdf |
| Scientific Opinion on the safety and efficacy of propionic acid, sodium propionate, calcium propionate and ammonium propionate for all animal species View page or View pdf |
| Scientific Opinion on safety and efficacy of sodium benzoate, propionic acid and sodium propionate for pigs, poultry, bovines, sheep, goats, rabbits, horses View page or View pdf |
| Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species View page or View pdf |
| Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):79-09-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :1032 |
| National Institute of Allergy and Infectious Diseases:Data |
| SCCNFP:opinion |
| WISER:UN 3463 |
| WGK Germany:1 |
| propanoic acid |
| Chemidplus:0000079094 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:79-09-4 |