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ortho-methoxycinnamaldehyde
General Material Information
| Preferred name | ortho-methoxycinnamaldehyde |
| Trivial Name | 2-Methoxycinnamaldehyde |
| Short Description | o-methoxycinnamaldehyde |
| Formula | C10 H10 O2 |
| CAS Number | 1504-74-1 |
| FEMA Number | 3181 |
| Flavis Number | 5.048 |
| ECHA Number | 216-131-3 |
| FDA UNII | 4940G3R6HE |
| Beilstein Number | 2436856 |
| MDL | MFCD00007001 |
| COE Number | 571 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 688 o-methoxycinnamaldehyde |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 1504-74-1 ; O-METHOXYCINNAMALDEHYDE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| 3-(2-methoxyphenyl)prop-2-enal | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 1504-74-1 |
| Pubchem (cid): | 15173 |
| Pubchem (sid): | 134979025 |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB33830 |
| FooDB: | FDB011997 |
| Export Tariff Code: | 2912.49.2000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 162.18809509277 |
| Melting Point | 44 to 48°C @ 760 mm Hg |
| Boiling Point | 160 to 161°C @ 12 mm Hg |
| Acid Value | 5 max KOH/g |
| Vapor Pressure | 0.000125 mmHg @ 25 °C |
| Flash Point TCC Value | 133.89 °C TCC |
| logP (o/w) | 2.37 est |
| Solubility | |
| alcohol | Yes |
| water, very slightly | Yes |
| water, 1598 mg/L @ 25 °C (est) | Yes |
| water | No |
Organoleptic Properties
| Odor Type: Spicy | |
| sweet, cinnamon, cassia, oily, woody, paper, cinnamyl, spicy, resinous | |
| Odor strength | medium |
| Substantivity | 48 hour(s) at 100.00 % |
| Luebke, William tgsc, (1985) | At 100.00 %. sweet cinnamon cassia oily woody paper |
| Mosciano, Gerard P&F 26, No. 3, 80, (2001) | At 5.00 %. Sweet, cinnamic, spicy, slightly woody and resinous nuances |
| Flavor Type: Spicy | |
| sweet, spicy, woody, cinnamon, medicinal, phenolic | |
| Mosciano, Gerard P&F 26, No. 3, 80, (2001) | At 5.00 - 25.00 ppm. Sweet, spicy, woody, cinnamon bark with medicinal and phenolic nuances |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Odor purposes | Balsam , Cassia , Cherry , Cinnamon , Clove , Gingerbread , Honey , Peru balsam , Raspberry , Spice , Tarragon oil replacer , Tonka bean , Vanilla , Woody |
| Flavoring purposes | Chocolate cacao , Tarragon oil replacer |
| Cosmetic purposes | Perfuming agents |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Human Experience: | |
| 4 % solution: no irritation or sensitization. | |
| Oral/Parenteral Toxicity: | |
| oral-mouse LD50 > 2000 mg/kg Japanese Kokai Tokyo Koho Patents. Vol. #92-360829 oral-rat LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 845, 1975. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 845, 1975. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| IFRA Critical Effect: | |||
| Dermal sensitization | |||
| View the IFRA Standard | |||
| View IFRA Standards Library for complete information. | |||
| Please review Amendment 49 IFRA documentation for complete information. | |||
| IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%): | |||
| Category 1: Products applied to the lips | |||
| 0.077 % | |||
| Category 2: Products applied to the axillae | |||
| 0.023 % | |||
| Category 3: Products applied to the face/body using fingertips | |||
| 0.46 % | |||
| Category 4: Products related to fine fragrance | |||
| 0.43 % | |||
| Category 5: Products applied to the face and body using the hands (palms), primarily leave-on | |||
| Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on | |||
| 0.11 % | |||
| Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on | |||
| 0.11 % | |||
| Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on | |||
| 0.11 % | |||
| Category 5D: Baby Creams, baby Oils and baby talc | |||
| 0.11 % | |||
| Category 6: Products with oral and lip exposure | |||
| 0.25 % | |||
| Category 7: Products applied to the hair with some hand contact | |||
| Category 7A: Rinse-off products applied to the hair with some hand contact | |||
| 0.88 % | |||
| Category 7B: Leave-on products applied to the hair with some hand contact | |||
| 0.88 % | |||
| Category 8: Products with significant anogenital exposure | |||
| 0.045 % | |||
| Category 9: Products with body and hand exposure, primarily rinse off | |||
| 0.84 % | |||
| Category 10: Household care products with mostly hand contact | |||
| Category 10A: Household care excluding aerosol products (excluding aerosol/spray products) | |||
| 3.00 % | |||
| Category 10B: Household aerosol/spray products | |||
| 3.00 % | |||
| Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate | |||
| Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure | |||
| 1.70 % | |||
| Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure | |||
| 1.70 % | |||
| Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin | |||
| No Restriction | |||
| Notes: | |||
| IFRA FLAVOR REQUIREMENTS: | |||
Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.49 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 71.00 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 4 | |||
| Click here to view publication 4 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 40.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | 450.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 30.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Flavouring Group Evaluation 214: alpha,beta-Unsaturated aldehydes and precursors from chemical subgroup 3.1 of FGE.19: Cinnamyl derivatives[1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 68 (FGE.68): Consideration of cinnamyl alcohol and related flavouring agents evaluated by JECFA (55th meeting) evaluated by EFSA in FGE.15Rev1 (2008) View page or View pdf |
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):1504-74-1 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :15173 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| 3-(2-methoxyphenyl)prop-2-enal |
| Chemidplus:29283147 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:GD6590000 for cas# 1504-74-1 |