| Preferred name | methyl anthranilate |
| Trivial Name | Methyl anthranilate |
| Short Description | benzoic acid, 2-amino-, methyl ester |
| Formula | C8 H9 N O2 |
| CAS Number | 134-20-3 |
| FEMA Number | 2682 |
| Flavis Number | 9.715 |
| ECHA Number | 205-132-4 |
| FDA UNII | 981I0C1E5W |
| Nikkaji Number | J2.018D |
| Beilstein Number | 0606965 |
| MDL | MFCD00007710 |
| COE Number | 250 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 1534 methyl anthranilate |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 134-20-3 ; METHYL ANTHRANILATE |
| Synonyms |
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| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
| methyl 2-aminobenzoate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 134-20-3 |
| Pubchem (cid): | 8635 |
| Pubchem (sid): | 134974914 |
| Flavornet: | 134-20-3 |
| Pherobase: | View |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C20634 |
| HMDB (The Human Metabolome Database): | HMDB29703 |
| FooDB: | FDB000897 |
| Export Tariff Code: | 2922.49.3700 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •grades: technical; fcc. •usepaopp pesticide code 128725; trade names: bird shield repellant concentrate (26.4%), rejex-it ag-145 (14.5%), rejex-it ag-36 (14.5%), rejex-it ma (98.5%), rejex-it tp-40 (40%). | |
| Material listed in food chemical codex | Yes |
| Molecular weight | 151.16513061523 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 9.661 to 9.727 |
| Refractive Index | 1.579 to 1.592 @ 20 °C |
| Melting Point | 23 to 24.5°C @ 760 mm Hg |
| Boiling Point | 238 to 241°C @ 760 mm Hg |
| Boiling Point | 163 to 164°C @ 50 mm Hg |
| Vapor Pressure | 0.016 mmHg @ 25 °C |
| Vapor Density | 5.2 |
| Flash Point TCC Value | 104.44 °C TCC |
| logP (o/w) | 1.88 |
| Shelf life | 12 months (or longer if stored properly.) |
| Storage notes | Store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Solubility | |
| alcohol | Yes |
| dipropylene glycol | Yes |
| fixed oils | Yes |
| propylene glycol | Yes |
| water, 2850 mg/L @ 25 °C (exp) | Yes |
| paraffin oil | No |
| glycerin | No |
| Stability | |
| alcoholic lotion | Unspecified |
| antiperspirant | Unspecified |
| deo stick | Unspecified |
| detergent perborate | Unspecified |
| fabric softener | Unspecified |
| liquid detergent | Unspecified |
| shampoo | Unspecified |
| soap | Unspecified |
| Odor Type: Fruity | |
| fruity, grape, orangeflower, neroli, musty, floral, powdery | |
| Odor strength | medium |
| Substantivity | 88 hour(s) at 100.00 % |
| Luebke, William tgsc, (1982) | At 100.00 %. fruity grape orangeflower neroli |
| Mosciano, Gerard P&F 18, No. 2, 38, (1993) | Fruity, concord grape, musty with a floral powdery nuance |
| Flavor Type: Fruity | |
| sweet, fruity, grape, musty, berry | |
| Mosciano, Gerard P&F 18, No. 2, 38, (1993) | At 25.00 ppm. Sweet, fruity, concord grape, with a musty and berry nuance |
| Used in a wide variety of flavors including grape, plum, blueberry and cherry. | Sweet fruity |
| General comment | Sweet fruity concord grape musty berry |
| (data available) |
| Applications | |
| Odor purposes | Acacia , Almond , Banana , Bergamot , Bluebell , Blueberry , Bouquet , Bubble gum , Champaca , Cherry , Citrus , Clove , Cologne , Currant , Elder flower , Floral , Gardenia , Genet , Grape concord grape , Greenhouse , Habuba , Jasmin , Leather , Lemon , Lily , Melon , Mulberry , Neroli , Orange , Orange blossom , Oriental , Passion fruit , Petitgrain mandarin oil replacer , Pine forest , Pineapple , Plum , Quince , Sweet pea , Tangerine , Tuberose , Violet , Wallflower , Woodruff , Ylang ylang |
| Flavoring purposes | Petitgrain mandarin oil replacer |
| Other purposes | Chloe , Poison , Quelques fleurs |
| Cosmetic purposes | Fragrance |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Acute aquatic toxicity (Category 2), H401 Chronic aquatic toxicity (Category 2), H411 | |
| GHS Label elements, including precautionary statements | |
| Pictogram | ![]() |
| Signal word | Warning |
| Hazard statement(s) | |
| H315 - Causes skin irritation H319 - Causes serious eye irritation H335 - May cause respiratory irritation H401 - Toxic to aquatic life H411 - Toxic to aquatic life with long lasting effects | |
| Precautionary statement(s) | |
| P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P264 - Wash skin thouroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P273 - Avoid release to the environment. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P302 + P352 - IF ON SKIN: wash with plenty of soap and water. P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 - Call a POISON CENTER or doctor/physician if you feel unwell. P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention. P337 + P313 - IF eye irritation persists: Get medical advice/attention. P362 - Take off contaminated clothing and wash before reuse. P391 - Collect spillage. Hazardous to the aquatic environment P403 + P233 - Store in a well-ventilated place. Keep container tightly closed. P405 - Store locked up. P501 - Dispose of contents/ container to an approved waste disposal plant. | |
| Human Experience: | |
| 10 % solution: no irritation or sensitization. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 2910 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. oral-mouse LD50 3900 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. oral-guinea pig LD50 2780 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 935, 1974. | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for methyl anthranilate usage levels up to: | |||
| 10.0000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 686.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 3764.00 (μg/capita/day) | ||
| Threshold of Concern: | 1800 (μg/person/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3. Update in publication number(s): 18 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 38.00000 | 38.00000 | |
| beverages(nonalcoholic): | 40.00000 | 40.00000 | |
| beverages(alcoholic): | 0.20000 | 2.00000 | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 200.00000 | 1583.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | 40.00000 | 40.00000 | |
| fruit ices: | 40.00000 | 40.00000 | |
| gelatins / puddings: | 20.00000 | 20.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 80.00000 | 161.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | 6.00000 | 6.00000 | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | 80.00000 | 80.00000 | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Flavouring Group Evaluation 84, (FGE.84)[1] - Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
| Scientific Opinion on the safety and efficacy of anthranilate derivatives (chemical group 27) when used as flavourings for all animal species View page or View pdf |
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):134-20-3 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :8635 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| methyl 2-aminobenzoate |
| Chemidplus:0000134203 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:CB3325000 for cas# 134-20-3 |