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methyl salicylate
General Material Information
| Preferred name | methyl salicylate |
| Trivial Name | Methyl salicylate |
| Short Description | benzoic acid, 2-hydroxy-, methyl ester |
| Formula | C8 H8 O3 |
| CAS Number | 119-36-8 |
| Deleted CAS Number | 648434-07-5 |
| FEMA Number | 2745 |
| Flavis Number | 9.749 |
| ECHA Number | 204-317-7 |
| FDA UNII | LAV5U5022Y |
| Nikkaji Number | J2.915G |
| Beilstein Number | 0971516 |
| MDL | MFCD00002214 |
| COE Number | 433 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 899 methyl salicylate |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 119-36-8 ; METHYL SALICYLATE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Literature & References
| methyl 2-hydroxybenzoate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 119-36-8 |
| Pubchem (cid): | 4133 |
| Pubchem (sid): | 134974376 |
| Flavornet: | 119-36-8 |
| Pherobase: | View |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C12305 |
| HMDB (The Human Metabolome Database): | HMDB34172 |
| FooDB: | FDB012459 |
| YMDB (Yeast Metabolome Database): | YMDB01370 |
| Export Tariff Code: | 2918.23.0000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •usp: liniment, compound: menthol 4.5 g, camphor oil rectified 25 ml, olive or peanut oil 30 ml, methyl salicylate to make 100 ml. ointment, compound: methyl salicylate 10 ml, menthol 10 g, white wax 5 g, hydrous wool fat to make 100 g. •usp: spirit, phenolated (podiatry): liquefied phenol 1 ml, methyl salicylate 3 ml, compound myrcia spirit 25 ml, alcohol rubbing compound to make 100 ml. •grades: technical; usp; fcc. | |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | Yes |
| Molecular weight | 152.14935302734 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 9.819 to 9.86 |
| Refractive Index | 1.535 to 1.538 @ 20 °C |
| Melting Point | -8 to -7°C @ 760 mm Hg |
| Boiling Point | 222 to 224°C @ 760 mm Hg |
| Boiling Point | 132 to 133°C @ 50 mm Hg |
| Acid Value | 1 max KOH/g |
| Vapor Pressure | 0.0343 mmHg @ 25 °C |
| Vapor Density | 5.26 |
| Flash Point TCC Value | 96 °C TCC |
| logP (o/w) | 2.55 |
| Shelf life | 24 months (or longer if stored properly.) |
| Storage notes | Store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Solubility | |
| alcohol | Yes |
| dipropylene glycol | Yes |
| kerosene | Yes |
| paraffin oil | Yes |
| water, 700 mg/L @ 30 °C (exp) | Yes |
| water | No |
| Stability | |
| non-discoloring in most media | Unspecified |
Organoleptic Properties
| Odor Type: Minty | |
| wintergreen, minty, sweet, root beer, aromatic, phenolic, camphoreous | |
| Odor strength | medium , recommend smelling in a 10.00 % solution or less |
| Substantivity | 8 hour(s) at 100.00 % |
| Luebke, William tgsc, (1983) | At 10.00 % in dipropylene glycol. wintergreen mint |
| Mosciano, Gerard P&F 20, No. 6, 49, (1995) | Sweet, salicylate, root beer, wintergreen, aromatic, slightly phenolic and camphoreous |
| Flavor Type: Minty | |
| sweet, wintergreen, root beer, aromatic, balsamic | |
| Mosciano, Gerard P&F 20, No. 6, 49, (1995) | At 10.00 ppm. Sweet, salicylate and root beer with aromatic and balsamic nuances |
| General comment | Sweet, wintergreen |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Odor purposes | Acacia , Alpine bouquet , Apple , Apricot , Blackberry , Blueberry , Boxwood berry , Bubble gum , Carnation , Cassia , Cassia blossom , Castoreum , Cherry , Chypre , Clove , Cornmint , Crabapple blossom , Cranberry , Currant , Currant bud absolute replacer , Date , Fern , Gardenia , Gooseberry , Grape , Hay new mown hay , Herbal , Huckleberry , Hyssop , Jasmin , Leather russian leather , Licorice , Magnolia , Meadowsweet , Mimosa , Mint , Mulberry , Oriental , Peach , Peppermint , Raspberry , Reseda , Root beer , Rue , Sassafras , Spearmint , Spice , Spicewood , Strawberry , Tea green tea , Tuberose , Valerian , Wallflower , Wintergreen , Wormwood oil replacer , Ylang ylang , Zibeline |
| Flavoring purposes | Beer birch beer , Cornmint , Currant bud absolute replacer , Grenadine , Hyssop , Rue , Sarsaparilla , Tomato , Valerian |
| Cosmetic purposes | Denaturants , Fragrance , Perfuming agents , Soothing agents |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| Acute toxicity, Oral (Category 4), H302 Acute aquatic toxicity (Category 3), H402 | |
| GHS Label elements, including precautionary statements | |
| Pictogram |  |
| Signal word | Warning |
| Hazard statement(s) | |
| H302 - Harmful if swallowed H402 - Harmful to aquatic life | |
| Precautionary statement(s) | |
| P264 - Wash skin thouroughly after handling. P270 - Do not eat, drink or smoke when using this product. P273 - Avoid release to the environment. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P330 - Rinse mouth. P501 - Dispose of contents/ container to an approved waste disposal plant. | |
| Human Experience: | |
| 8 % solution: no irritation or sensitization. | |
| Oral/Parenteral Toxicity: | |
| gavage-mouse LD50 [sex: M] 1390 mg/kg (Ohsumi et al., 1984) gavage-rat LD50 1250 mg/kg (Giroux et al., 1954b) oral-rat LD50 [sex: M,F] M:3049.00 F:2642 mg/kg (Givaudan Corporation, 1982) gavage-rat LD50 [sex: M,F] 887 mg/kg (Jenner et al., 1964) oral-rat LD50 1220 mg/kg (Nivikov et al., 1994) oral-mouse LD50 [sex: M] 1110 mg/kg (Davison et al., 1961) gavage-guinea pig LD50 [sex: M,F] 1060 mg/kg (Jenner et al., 1964) gavage-mouse LD50 [sex: M,F] 1440 mg/kg (NTP, 1984a) oral-woman LDLo 355 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: COMA American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937. oral-rat LD50 887 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. oral-rabbit LD50 1300 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. oral-mouse LD50 1110 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 207, 1961. unreported-man LDLo 522 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-man LDLo 1329 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA BLOOD: HEMORRHAGE Clinical Toxicology. Vol. 6, Pg. 189, 1973. oral-man LDLo 101 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937. oral-human LDLo 506 mg/kg "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 961, 1989. oral-guinea pig LD50 700 mg/kg "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63Vol. 2, Pg. 1897, 1963. oral-dog LD50 2100 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. oral-child LDLo 700 mg/kg BEHAVIORAL: GENERAL ANESTHETIC PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Archives of Disease in Childhood. Vol. 28, Pg. 475, 1953. oral-child LDLo 228 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: DYSPNEA American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945. | |
| Dermal Toxicity: | |
| subcutaneous-dog LDLo 2250 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. subcutaneous-guinea pig LDLo 1500 mg/kg FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 63, 1967. subcutaneous-rabbit LDLo 4250 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| cosmetic, flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| maximum skin levels for fine fragrances: | |||
| 0.2900 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey).(IFRA, 2002) | |||
| Recommendation for methyl salicylate usage levels up to: | |||
| 10.0000 % in the fragrance concentrate. | |||
| use level in formulae for use in cosmetics: | |||
| 0.1300 % | |||
| Dermal Systemic Exposure in Cosmetic Products: | |||
| 0.0034 mg/kg/day (IFRA, 2002) | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 410.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 44000.00 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 54.00000 | |
| beverages(nonalcoholic): | - | 59.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | 8400.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 27.00000 | |
| fruit ices: | - | 27.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 840.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
| Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
| Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
| Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):119-36-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :4133 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 3082 |
| WGK Germany:1 |
| methyl 2-hydroxybenzoate |
| Chemidplus:0000119368 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:119-36-8 |