We have found
46590
results matching your criteria.
Please wait while we search...
2-methyl thio-3,5 or 6-methyl pyrazine
General Material Information
| Preferred name | 2-methyl thio-3,5 or 6-methyl pyrazine |
| Trivial Name | Methyl(methylthio)pyrazine |
| Short Description | (3, 5 or 6)-methylthio-2-methylpyrazine |
| Formula | C6 H8 N2 S |
| CAS Number | 67952-65-2 |
| FEMA Number | 3208 |
| Flavis Number | 14.035 |
| ECHA Number | 267-918-3 |
| FDA UNII | Search |
| Nikkaji Number | J113.403E |
| Beilstein Number | 0774815 |
| MDL | MFCD00053111 |
| COE Number | 2290 |
| xLogP3-AA | 0.30 (est) |
| NMR Predictor | External link |
| JECFA Food Flavoring | 797 (3, 5 or 6)-methylthio-2-methylpyrazine |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 67952-65-2 ; 2-METHYL-(3 OR 5 OR 6)-(METHYLTHIO)PYRAZINE (MIXTURE OF ISOMERS) |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| HMDB (The Human Metabolome Database): | HMDB32384 |
| FooDB: | FDB009804 |
| Export Tariff Code: | 2933.90 |
| ChemSpider: | View |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 140.20875549316 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 9.503 to 9.586 |
| Refractive Index | 1.575 to 1.585 @ 20 °C |
| Boiling Point | 210 to 211°C @ 760 mm Hg |
| Vapor Pressure | 0.161 mmHg @ 25 °C |
| Vapor Density | 4.8 |
| Flash Point TCC Value | 89.44 °C TCC |
| logP (o/w) | 0.153 est |
| Solubility | |
| alcohol | Yes |
| dipropylene glycol | Yes |
| water, 3390 mg/L @ 25 °C (est) | Yes |
| water | No |
Organoleptic Properties
| Odor Type: Nutty | |
| nutty, earthy, peanut, musty, coffee, vegetable, toasted, popcorn, roasted, almond, hazelnut, cashew, caramellic, corn chip | |
| General comment | At 0.10 % in dipropylene glycol. nutty earthy peanut musty coffee vegetable |
| Mosciano, Gerard P&F 25, No. 3, 25, (2000) | At 1.00 %. Toasted popcorn, roasted almond, hazelnut, peanut and cashew nutty, with a caramellic and corn-chip nuance |
| Flavor Type: Nutty | |
| peanut, pecan, nutty, popcorn, corn chip, burnt, musty | |
| Mosciano, Gerard P&F 25, No. 3, 25, (2000) | At 3.00 - 10.00 ppm. Peanut and pecan nutty, popcorn and corn-chip-like with a burnt musty nuance |
| Used in roast nut, chocolate and bread flavorus. The COE# 2290 is for 2-methyl-3-thiomethylpyrazine (not the isomeric mixture). Normal use levels in finished consumer product: 0.02-2 ppm. Council of Europe limits: Foods (4 ppm). | Nutty |
Potential Uses
| Applications | |
| Odor purposes | Coffee , Hazelnut , Peanut , Popcorn |
| Flavoring purposes | Almond toasted almond , Bread , Cabbage , Chocolate cocoa , Corn chip , Macadamia , Pecan |
| Other purposes | Straw |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| gavage-rat LD50 1970 mg/kg (Posternak et al., 1975) | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for 2-methyl thio-3,5 or 6-methyl pyrazine usage levels up to: | |||
| 0.1000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 6.30 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 13.00 (μg/capita/day) | ||
| Structure Class: | III | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 4 | |||
| Click here to view publication 4 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 4.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 2.00000 | |
| fruit ices: | - | 2.00000 | |
| gelatins / puddings: | - | 2.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 2.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
| Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):67952-65-2 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :100930 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2-methyl-3-methylsulfanylpyrazine |
| Chemidplus:0067952652 |
| RTECS:UQ3900000 for cas# 67952-65-2 |