phenoxyethanol

General Material Information

Preferred name	phenoxyethanol
Trivial Name	Phenoxyethanol
Short Description	2-(phenoxy)ethanol
Formula	C8 H10 O2
CAS Number	122-99-6
Deleted CAS Number	37220-49-8
FEMA Number	4620
ECHA Number	204-589-7
FDA UNII	HIE492ZZ3T
Nikkaji Number	J5.360K
Beilstein Number	1364011
MDL	MFCD00002857
Bio Activity Summary	External link
NMR Predictor	External link
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	122-99-6 ; ETHYLENE GLYCOL MONOPHENYL ETHER
Synonyms	1160 rose ether alcool phenoxyethylique arosol cosept PEP dowanol EP emeressence 1160 rose ether ethanol, 2-phenoxy- ethylene glycol monophenyl ether ethylene glycol phenyl ether glycol monophenyl ether 1-hydroxy-2-phenoxyethane 2-hydroxyethyl phenyl ether beta- hydroxyethyl phenyl ether igepal OD 410 phenoxetol phenoxy ethanol phenoxy ethanol (rose ether) 2-( phenoxy)ethanol 2-phenoxy-ethanol 2-phenoxyethan-1-ol 2-phenoxyethanol beta- phenoxyethanol 2-phenoxyethanol NF/BP grade 2-phenoxyethanol NF/EP grade phenoxyethyl alcohol phenoxytol phenyl cellosolve phenyl monoglycol ether phenylglycol rose ether rose ether 1160 symocide PS (phenoxy ethanol, 1,2 hexanediol, decylene glycol) symocide PS (Symrise) symocide PT (Symrise) tristat P5 undebenzofene-C (Vevy) undebenzofene-C P-F (Vevy) 2-phenoxyethanol β-Hydroxyethyl phenyl ether 1-Hydroxy-2-phenoxyethane Phenoxethol 2-Hydroxyethyl phenyl ether β-Phenoxyethyl alcohol β-Phenoxyethanol 2-Phenoxyethyl alcohol Dalpad A Dowanol EPh H 4644 Newpol EFP (2-Hydroxyethoxy)benzene Rokafenol F 1 Plastilit DS 3431 PHE-G Phenova PHE PHE (alcohol) PHE-S NSC 1864 Sepicide LD Hisolve EPH Emeressence 1160 Euxyl PE 90120 Agrisol PX 401 Ultrasolve P 240A PhG RGP 55 Protectol PE Glycol Ether EPh Phenyl Glycol JS-EPh Neolone PH 100 HYSOLVE EPH Kafurekuto PE 1 Phenoxyethanol SP Acticide PHE Microcare PE Phenoxitol Phenoxetol NF 272556 Acticide SR 150 PHG-S Protectol PE-CO Phenoxetol NF Gluadin WQ-PP

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

	2-phenoxyethanol
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	122-99-6
Pubchem (cid):	31236
Pubchem (sid):	134974207
Pherobase:	View

Publications by US Patents
5,585,343 - Low VOC perfume formulations
Publications by PubMed
Development of a multi-preservative method based on solid-phase microextraction-gas chromatography-tandem mass spectrometry for cosmetic analysis.
Contact sensitivity to preservatives in Singapore: frequency of sensitization to 11 common preservatives 2006-2011.
Occurrence of preservatives and antimicrobials in Japanese rivers.
Urinary glycol ether metabolites in women and time to pregnancy: the PELAGIE cohort.
Migration of plasticisers from Tritan and polycarbonate bottles and toxicological evaluation.
Bacterial Growth Kinetics under a Novel Flexible Methacrylate Dressing Serving as a Drug Delivery Vehicle for Antiseptics.
Comparison of the effects of four anaesthetics on haematological and blood biochemical profiles in pikeperch (Sander lucioperca L.).
Physiological responses of great sturgeon (Huso huso) to different concentrations of 2-phenoxyethanol as an anesthetic.
Hypersensitivity reactions to vaccine constituents: a case series and review of the literature.
Comparison of the antiseptic efficacy of tissue-tolerable plasma and an octenidine hydrochloride-based wound antiseptic on human skin.
A study of the evaporation of a solvent from a solution--application to writing ink aging.
Anaesthesia of farmed fish: implications for welfare.
Fragrance material review on 2-phenoxyethanol.
The percutaneous permeation of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept®) through skin of different species in vitro.
Vibrational spectra and assignments of 2-phenylethanol and 2-phenoxyethanol.
Preservative of choice for Prev(e)nar 13™ in a multi-dose formulation.
Effects of ethylene glycol ethers on cell viability in the human neuroblastoma SH-SY5Y cell line.
Pseudomonas aeruginosa PAO1 adapted to 2-phenoxyethanol shows cross-resistance to dissimilar biocides and increased susceptibility to antibiotics.
[Wound closure after irrigation with Octenisept® without possibility for drainage].
A New Validated HPLC Method for the Simultaneous Determination of 2-phenoxyethanol, Methylparaben, Ethylparaben and Propylparaben in a Pharmaceutical Gel.
Development and Validation of a RPLC Method for the Determination of 2-Phenoxyethanol in Senselle Lubricant Formulation.
Immunogenicity of HBV vaccine during stated shelf-life.
2-Phenoxyethanol derived diselenide and related compounds; synthesis of a seven-membered seleninate ester.
The most important contact sensitizers in Polish children and adolescents with atopy and chronic recurrent eczema as detected with the extended European Baseline Series.
2-phenoxyethanol-induced contact urticaria and anaphylaxis.
Ocular symptoms, tear film stability, nasal patency, and biomarkers in nasal lavage in indoor painters in relation to emissions from water-based paint.
Aerobic oxidation of lignin models using a base metal vanadium catalyst.
The relative toxicity of compounds used as preservatives in vaccines and biologics.
The effect of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) on wound healing in pigs in vivo and its in vitro percutaneous permeation through intact and barrier disrupted porcine skin.
[Contact sensitization to Euxyl K-400].
Contact dermatitis due to use of Octenisept in wound care.
[Simultaneous determination of adapalene, 2-phenoxyethanol and methyl-4-hydroxybenzoate in adapalene gels using high performance liquid chromatography].
2-Phenoxyethanol as anaesthetic in removing relocating 102 species of fishes representing from Sea World to uShaka Marine World, South Africa.
Comparison of acute toxicity of 2-phenoxyethanol and clove oil to juvenile and embryonic stages of Danio rerio.
Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne.
Simultaneous determination of 21 preservatives in cosmetics by ultra performance liquid chromatography.
Development of an SPME-GC-MS/MS procedure for the monitoring of 2-phenoxyethanol in anaesthetised fish.
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine.
Preparation and solution behavior of a thermoresponsive diblock copolymer of poly(ethyl glycidyl ether) and poly(ethylene oxide).
[Effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine and its safety].
Ballpoint pen inks: the quantitative analysis of ink solvents on paper by solid-phase microextraction.
Role of (3Z,6Z,8E)-dodecatrien-1-ol in trail following, feeding, and mating behavior of Reticulitermes hesperus.
Mechanism of anaerobic degradation of triethanolamine by a homoacetogenic bacterium.
2-phenoxyethanol-induced contact urticaria.
Hypersensitivity reactions to vaccine components.
[Aspects of animal welfare and species protection in the international trade of ornamental fish and air transport to Germany].
Effect of biocides on S. cerevisiae: relationship between short-term membrane affliction and long-term cell killing.
Postoperative ascites associated with intraperitoneal antiseptic lavage.
Generation and reactivity of ketyl radicals with lignin related structures. On the importance of the ketyl pathway in the photoyellowing of lignin containing pulps and papers.
Cutaneous metabolism of glycol ethers.
Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG).
Total serum immunoglobulin M levels are affected by immunomodulators in seabream (Sparus aurata L.).
[Hygienic standards of the occupational air quality established by the Experts on Chemical Agents, 2002].
The identification of 2-phenoxyethanol in ballpoint inks using gas chromatography/mass spectrometry--relevance to ink dating.
Effects of different stressor agents on gilthead seabream natural cytotoxic activity.
Sensitive determination of alkoxyethanols by pre-column derivatization with 1-anthroylnitrile and reversed-phase high-performance liquid chromatography.
Characterization and aging study of currency ink and currency canine training aids using headspace SPME/GC-MS.
To fix or not to fix: the role of 2-phenoxyethanol in rabbit, Oryctolagus cuniculus, chin gland secretion.
Model compound studies of the beta-O-4 linkage in lignin: absolute rate expressions for beta-scission of phenoxyl radical from 1-phenyl-2-phenoxyethanol-1-yl radical.
Contact urticaria from 2-phenoxyethanol.
Use of 2% 2-phenoxyethanol and 0.1% octenidine as antiseptic in premature newborn infants of 23-26 weeks gestation.
Effects of four anaesthetics on the innate immune response of gilthead seabream (Sparus aurata L.).
In vitro induction of apoptosis vs. necrosis by widely used preservatives: 2-phenoxyethanol, a mixture of isothiazolinones, imidazolidinyl urea and 1,2-pentanediol.
Lack of effect of combining different stressors on innate immune responses of seabream (Sparus aurata L.).
Mechanism of anaerobic ether cleavage: conversion of 2-phenoxyethanol to phenol and acetaldehyde by Acetobacterium sp.
The first example of a paraben-dependent antibody to an Rh protein.
[Branch-specific detection of phenols and assessment of ground water solubility].
Analytical control of preservative labelling on skin creams.
2-Phenoxyethanol: a neurotoxicant?
P(MeNCH2CH2)3N: an efficient catalyst for the desilylation of tert-butyldimethylsilyl ethers
Modulation of stress hormones in rainbow trout by means of anesthesia, sensory deprivation and receptor blockade.
Effects of 2-phenoxyethanol on N-methyl-D-aspartate (NMDA) receptor-mediated ion currents.
Percutaneous penetration of 2-phenoxyethanol through rat and human skin.
High-performance liquid chromatographic determination of oxolinic acid in the plasma of seabass (Dicentrarchus labrax) anaesthetized with 2-phenoxyethanol.
Flow-cytometric screening for the modulation of receptor-mediated endocytosis in human dendritic cells: implications for the development of an in vitro technique for predictive testing of contact sensitizers.
The sensitizing potency of Euxyl K 400 and its components 1,2-dibromo-2,4-dicyanobutane and 2-phenoxyethanol.
Continuous-wave dye lasers in the DCM region.
Use of 2-phenoxyethanol as an anaesthetic agent in goldfish (Cyprinus carpio).
Euxyl K 400: a new sensitizer in cosmetics.
Occupational phenoxyethanol neurotoxicity: a report of three cases.
Inhibitory effect of anaesthesia with 2-phenoxyethanol as compared to MS222 on glucose release in isolated hepatocytes from rainbow trout (Salmo gairdneri).
Sensitization studies in the guinea pig with the active ingredients of Euxyl K 400.
Teratologic evaluation of 2-phenoxyethanol in New Zealand White rabbits following dermal exposure.
Selectivity and sensitivity of some thin-layer chromatographic detection systems.
Cell wall-mediated changes in sensitivity of Bacillus megaterium to chlorhexidine and 2-phenoxyethanol, associated with growth rate and nutrient limitation.
Effect of 2-phenoxyethanol upon RNA, DNA and protein biosynthesis in Escherichia coli NCTC 5933.
Effect of R-plasmid RP1 and nutrient depletion on the gross cellular composition of Escherichia coli and its resistance to some uncoupling phenols.
The lethal action of 2-phenoxyethanol and its analogues upon Escherichia coli NCTC 5933.
Chlorhexidine resistance in Proteus mirabilis.
Killing and preserving nematodes in soil samples with chemicals and microwave energy.
Phenoxyethanol: protein preservative for taxonomists.
PRESERVATIVES FOR POLIOMYELITIS (SALK) VACCINE. 3. 2-PHENOXYETHANOL.
The action of phenol and 2-phenoxyethanol on the oxidation of various substances by Escherichia coli and by a disrupted cell preparation of the organism.
The effect of phenol, 2-phenoxyethanol and cetyltrimethylammonium bromide on the oxidation of various substrates by Escherichia coli.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
FDA Indirect Additives used in Food Contact Substances:	View
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	D08359
HMDB (The Human Metabolome Database):	HMDB41607
FooDB:	FDB021762
YMDB (Yeast Metabolome Database):	YMDB01591
Export Tariff Code:	2909.50.5000
Typical G.C.
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
Formulations/Preparations: grade: technical

Suppliers

Acme-Hardesty	American International Chemical, LLC.
Augustus Oils	Berjé
BOC Sciences	LBB Specialties
Connect Chemicals	ECSA Chemicals
HallStar	Indukern F&F
Jiangyin Healthway	Kingyoung Bio Technical
Kraft Chemical	Lluch Essence
Moellhausen	OQEMA
Penta International	Prasad Organics
Prodasynth	Sarchem Laboratories
Sigma-Aldrich	Silver Fern Chemical
Spec-Chem Industry	Symrise
Synerzine	SysKem Chemie
TCI AMERICA	The John D. Walsh Company
TRI-K Industries	Universal Preserv-A-Chem Inc.
Vevy Europe	Vigon International
Augustus Oils Ltd	Indukern, S.A. F&F Ingredients Division
Jiangyin Healthway International Trade Co., Ltd	Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	138.16610717773
Specific gravity	@ 25 °C
Pounds per Gallon	9.195 to 9.22
Refractive Index	1.537 to 1.54 @ 20 °C
Melting Point	12 to 14°C @ 760 mm Hg
Boiling Point	237 to 238°C @ 760 mm Hg
Boiling Point	153 to 154°C @ 50 mm Hg
Vapor Pressure	0.016 mmHg @ 25 °C
Flash Point TCC Value	121.11 °C TCC
logP (o/w)	1.16
Solubility
alcohol	Yes
paraffin oil, slightly soluble	Yes
water, 26700 mg/L @ 20 °C (exp)	Yes
water	No

Organoleptic Properties

Odor Type: Floral
rose, balsamic, cinnamyl
Odor strength	medium
Substantivity	84 hour(s) at 100.00 %
Luebke, William tgsc, (1987)	At 100.00 %. mild rose balsam cinnamyl
General comment	Weak, mild, rosy, balsamic, cinnamon-like, fixative and solvent

Occurrences

Potential Uses

Applications	flavor and fragrance agents
Odor purposes	Acacia , Aldehydic , Almond , Amber , Ambrene , Angel essence , Apple blossom , Apricot , Balsam , Blue grass , Blue mist , Bluebell , Blueberry , Botanical , Bouquet , Carnation , Champaca , Cherry , Cherry blossom , Chestnut blossom , Civet , Coconut tropical coconut , Country meadow , Crabapple blossom , Currant , Elder berry , Fern , Fetes , Floral , Frangipani plumeria , Gardenia , Genet , Geranium , Ginger white ginger , Gooseberry , Hawthorn , Heather , Heliotrope , Herbal , Hibiscus , Honeysuckle , Hop , Hyacinth , Jasmin , Jonquil , Kiwi blossom , Leather , Lemon , Lilac , Lily , Lily of the valley , Linden flower , Lotus , Magnolia , Mulberry , Narcissus , Neroli , Orange blossom , Orchid , Oriental , Orris , Peach , Peony , Potpourri , Powder , Rain , Raspberry , Rose , Rose leaf , Rose red rose , Rose tea rose , Rose white rose , Sandalwood , Spice , Strawberry , Sweet pea , Tea green tea , Tuberose , Violet , Wallflower , Woody , Ylang ylang
Flavoring purposes	Rose leaf , Tea black tea
Other purposes	Antibacterial agents , Bellodgia , Fixer , Preservatives , Quelques fleurs
Cosmetic purposes	Preservatives

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed. R 36 - Irritating to eyes. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37 - Wear suitable gloves.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1260 mg/kg BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. intraperitoneal-mouse LD50 490 mg/kg BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996. oral-mouse LD50 933 mg/kg BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996. intraperitoneal-rat LD50 554 mg/kg BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996.
Dermal Toxicity:
skin-rabbit LD50 5 ml/kg Union Carbide Data Sheet. Vol. 6/24/1958 skin-rat LD50 14422 mg/kg LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA Journal of the American College of Toxicology. Vol. 9, Pg. 259, 1990.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for phenoxyethanol usage levels up to:
	5.0000 % in the fragrance concentrate.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
		average usual ppm	average maximum ppm
baked goods:		4.00000	8.00000
beverages(nonalcoholic):		0.50000	2.00000
beverages(alcoholic):		1.00000	3.00000
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		2.00000	5.00000
fruit ices:		1.00000	2.00000
gelatins / puddings:		1.00000	3.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		1.00000	5.00000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		1.00000	5.00000
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-