We have found 46590 results matching your criteria.
Please wait while we search...
  1. 1.
    General Material Information
  2. 2.
    PhysChem Properties
  3. 3.
    Occurrences
  4. 4.
    Organoleptic Properties
  5. 5.
    Suppliers
  6. 6.
    Potential Uses
  7. 7.
    Regulatory & Documentation
  8. 8.
    Safety Information
  9. 9.
    Other Information
  10. 10.
    Blenders & Components
  11. 11.
    Literature & References

dextro-camphor

Chemical Structure

General Material Information

Preferred name dextro-camphor
Trivial Name (+)-Camphor
Short Description D-camphor
Formula C10 H16 O
CAS Number 464-49-3
Deleted CAS Number 68546-28-1
FEMA Number 2230
Flavis Number 7.215
ECHA Number 207-355-2
FDA UNII N20HL7Q941
Nikkaji Number J43.294F
Beilstein Number 2042745
MDL MFCD00064149
COE Number 140
xLogP3-AA 2.20 (est)
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1395 D-camphor
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 464-49-3 ; D-CAMPHOR
Synonyms
  • bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1R,4R)-
  • bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R,4R)-
  • (+)- bornan-2-one
  • (+)-2-bornanone
  • (1R)- * (+)-2-bornanone
  • D-2-bornanone
  • dextro-2-bornanone
  • D-2-camphanone
  • dextro-2-camphanone
  • (+)- camphor
  • (1R,4R)-(+)- camphor
  • (1R)- camphor
  • (1R)- * (+)- camphor
  • (1R)-(+)- camphor
  • (R)- camphor
  • (R)-(+)- camphor
  • D- camphor
  • D-(+)- camphor
  • D-formosa camphor
  • D-laurel camphor
  • dextro-(+)- camphor
  • dextro-formosa camphor
  • dextro-laurel camphor
  • japanese camphor
  • camphor (gum) powder USP
  • camphor (gum) powder, technical
  • camphor flake USP24
  • camphor gum
  • camphor gum natural
  • camphor gum synthetic
  • camphor powder
  • camphor powder natural
  • camphor powder natural USP/FCC
  • camphor powder synthetic
  • camphor-D natural
  • camphor, (1R,4R)-(+)-
  • D- gum camphor
  • dextro- gum camphor
  • (R)-1,7,7-trimethyl bicyclo(2.2.1)-2-heptanone
  • (1R)-1,7,7-trimethyl bicyclo(2.2.1)heptan-2-one
  • 2-keto-1,7,7-trimethyl norcamphane
  • (R)-1,7,7-trimethylbicyclo(2.2.1)-2-heptanone
  • (1R,4R)-1,7,7-trimethylbicyclo(2.2.1)heptan-2-one
  • (1R)-1,7,7-trimethylbicyclo(2.2.1)heptan-2-one
  • (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
  • (1R,4R)-1,7,7-trimethylnorbornan-2-one
  • 2-keto-1,7,7-trimethylnorcamphane
  • (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
  • Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)-
  • (+)-Camphor
  • d-Camphor
  • D-(+)-Camphor
  • Camphor, (+)-
  • (+)-2-Bornanone
  • Alcanfor
  • (R)-(+)-Camphor
  • (1R)-Camphor
  • (R)-Camphor
  • (1R)-(+)-Camphor
  • (1R,4R)-(+)-Camphor
  • (+)-(1R,4R)-Camphor
  • (1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
  • Dextrocamphora

US / EU / FDA / JECFA / FEMA / Scholar / Patents

Google Scholar Start search
Google Books Start search
Google Patents Start search
Perfumer & Flavorists Start search
EU Patents Start search
PubMeb Start search
NCBI Start search

Literature & References

Leffingwell:Chirality or Article
(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:464-49-3
Pubchem (cid):159055
Pubchem (sid):134973831
Publications by PubMed
Total synthesis of chiriquitoxin, an analogue of tetrodotoxin isolated from the skin of a dart frog.
Hot-spot residues in the cytochrome P450cam-putidaredoxin binding interface.
Optically pure, monodisperse cis-oligodiacetylenes: aggregation- induced chirality enhancement.
[About flavouring substances and flavouring preparations regulation in the field of manufacturing of flavourings and foodstuffs].
Reaction of an "invisible" frustrated N/B Lewis pair with dihydrogen.
Nona-coordinated chiral Eu(III) complexes with stereoselective ligand-ligand noncovalent interactions for enhanced circularly polarized luminescence.
Desymmetrization of cyclohexadienones viad-camphor-derived triazolium salt catalyzed intramolecular Stetter reaction.
In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum.
Spectroscopic evidence for the unusual stereochemical configuration of an endosome-specific lipid.
Analysis of volatile compositions of Magnolia biondii pamp by steam distillation and headspace solid phase micro-extraction.
Formation of repressor-inducer-operator ternary complex: negative cooperativity of d-camphor binding to CamR.
Topological and experimental approach to the pressure-temperature-composition phase diagram of the binary enantiomer system d- and l-camphor.
Changing the substrate specificity of P450cam towards diphenylmethane by semi-rational enzyme engineering.
Breeding and identification of novel koji molds with high activity of acid protease by genome recombination between Aspergillus oryzae and Aspergillus niger.
Improvement of the embryonic stem cell test endpoint analysis by use of field potential detection.
Preparation of functionalized cyclic enol phosphates by halogen-magnesium exchange and directed deprotonation reactions.
Circularly polarized luminescence of Eu(III) complexes with point- and axis-chiral ligands dependent on coordination structures.
Highly enantioselective intramolecular Michael reactions by D-camphor-derived triazolium salts.
Resolution of planar chiral cationic (eta6-arene)tricarbonylmanganese complexes.
Biotransformations of (+/-)-geosmin by terpene-degrading bacteria.
D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly - a randomized, placebo controlled double blind study.
Skin disposition of d-camphor and l-menthol alone and together.
Tetraaquabis(D-camphor-10-sulfonato)calcium(II).
A role of the heme-7-propionate side chain in cytochrome P450cam as a gate for regulating the access of water molecules to the substrate-binding site.
Diamagnetic lanthanide tris beta-diketonates as organic-soluble chiral NMR shift reagents.
D-Camphor-derived triazolium salts for catalytic intramolecular crossed aldehyde-ketone benzoin reactions.
Hexaaqua-magnesium(II) bis-(d-camphor-10-sulfonate).
Polyploid formation between Aspergillus niger and Trichoderma viride for enhanced citric acid production from cellulose.
Preparation of highly conductive, self-assembled gold/polyaniline nanocables and polyaniline nanotubes.
Expression, crystallization and preliminary diffraction studies of the Pseudomonas putida cytochrome P450cam operon repressor CamR.
[Efficacy and safety of a herbal drug containing hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic cohort study].
A randomized trial of Korodin Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension.
Detection of a high-barrier conformational change in the active site of cytochrome P450cam upon binding of putidaredoxin.
L358P mutation on cytochrome P450cam simulates structural changes upon putidaredoxin binding: the structural changes trigger electron transfer to oxy-P450cam from electron donors.
Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam.
Discriminative power of an assay for automated in vitro screening of teratogens.
NMR study on the structural changes of cytochrome P450cam upon the complex formation with putidaredoxin. Functional significance of the putidaredoxin-induced structural changes.
Dose-response related efficacy in orthostatic hypotension of a fixed combination of D-camphor and an extract from fresh crataegus berries and the contribution of the single components.
A delicate balance of energetics. Subtleties associated with alpha-ketol-based bridge migration to afford 9-keto-10beta-p-methoxybenzyloxytaxanes.
Optical cell with a temperature-control unit for a vacuum-ultraviolet circular dichroism spectrophotometer.
Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension.
Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods.
Energetic stabilization of d-camphor via weak neutral currents.
Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system.
Putidaredoxin-cytochrome P450cam interaction.
X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center.
Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site.
In vitro transcriptional analysis of the cytochrome P-450cam hydroxylase operon.
Construction and application of MCBL plate for facilitation of chromosome recombination in fungi.
Putidaredoxin-cytochrome p450cam interaction. Spin state of the heme iron modulates putidaredoxin structure.
Reproductive toxicity studies of D-camphor in rats and rabbits.
Preparation of Enantiomerically Enriched (2R,3R)- or (2S,3S)-trans-2,3-Diaryloxiranes via Camphor-Derived Sulfonium Ylides.
NMR studies of recombinant cytochrome P450cam mutants.
Purification and characterization of a cam repressor (CamR) for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid.
Substrate interactions in cytochrome P-450: correlation between carbon-13 nuclear magnetic resonance chemical shifts and C-O vibrational frequencies.
Thermodynamic aspects of the CO-binding reaction to cytochrome P-450cam. Relevance with their biological significance and structure.
Heterologous expression of the cytochrome P450cam hydroxylase operon and the repressor gene of Pseudomonas putida in Escherichia coli.
High-pressure flash photolysis study of hemoprotein: effects of substrate analogues on the recombination of carbon monoxide to cytochrome P450CAM.
Significant contribution of arginine-112 and its positive charge of Pseudomonas putida cytochrome P-450cam in the electron transport from putidaredoxin.
Spectral intermediate in the reaction of ferrous cytochrome P450cam with superoxide anion.
Putative functions of phenylalanine-350 of Pseudomonas putida cytochrome P-450cam.
Transcription of the cam operon and camR genes in Pseudomonas putida PpG1.
Development of bacterial cytochrome P-450(cam) (cytochrome m) production.
[d-Camphor reference standard (Control 911) and dl-Camphor Reference Standard (Control 911) of the National Institute of Hygienic Sciences].
Observation of the O-O stretching Raman band for cytochrome P-450cam under catalytic conditions.
Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate.
[d-Camphor Reference Standard (Control 901) and dl-Camphor Reference Standard (Control 901) of National Institute of Hygienic Sciences].
Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and putidaredoxin gene (camB) involved in cytochrome P-450cam hydroxylase of Pseudomonas putida.
Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.
Theoretical study of the product specificity in the hydroxylation of camphor, norcamphor, 5,5-difluorocamphor, and pericyclocamphanone by cytochrome P-450cam.
Oxime-metabolizing activity of liver aldehyde oxidase.
[D-camphor-beta-sulfonic acid as an ion-pair reagent for the determination of biogenic amines and their metabolites in the rat brain by reverse phase high performance liquid chromatography].
Anticonvulsant properties of spirohydantoins derived from optical isomers of camphor.
[Central depressant effect of l-tetrahydroberberine-d-camphor sulfonate (THB-CS). Electroencephalographic study].
High-pressure investigations of cytochrome P-450 spin and substrate binding equilibria.
Novel reactivity of cytochrome P-450-CAM. Methyl hydroxylation of 5,5-difluorocamphor.
Regioselectivity in the cytochromes P-450: control by protein constraints and by chemical reactivities.
Proton coupling in the ligand-binding reaction of ferric cytochrome P-450 from Pseudomonas putida.
Sequential cold-sensitive mutations in Aspergillus fumigatus. II. Analysis by the parasexual cycle.
Cytochrome P-450cam and putidaredoxin interaction during electron transfer.
Magnetic circular dichroism of Pseudomonas putida cytochrome P-450 in near infrared region.
Growth inhibition of Vibrio cholerae by d-camphor.
Inhibition of oxidative metabolism in Escherichia coli by d-camphor and restoration of oxidase activity by quinones.
Growth inhibition of Escherichia coli strain 82-r by d-camphor.
Proton magnetic resonance reveals high-spin iron (II) in ferrous cytochrome P450 cam from Pseudomonas putida.
Induction specificity and catabolite repression of the early enzymes in camphor degradation by Pseudomonas putida.
Approximation of rotational strengths from molar rotation data and generation of rotatory dispersion curves for d-camphor-10-sulfonate.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C00808
HMDB (The Human Metabolome Database):Search
FooDB:FDB009067
Export Tariff Code:2914.21.1000
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 152.23672485352
Vapor Pressure 4 mmHg @ 25 °C
Vapor Density 5.24
Flash Point TCC Value 64.44 °C TCC
logP (o/w) 3.04
Solubility
alcohol Yes
water, 100 mg/L @ 25 °C (exp) Yes
water No
glycerin No

Organoleptic Properties

Odor Type: Camphoreous
camphoreous, minty, phenolic, herbal, woody, medicinal, mentholic, cooling, green
Odor strength high , recommend smelling in a 10.00 % solution or less
Substantivity 160 hour(s) at 20.00 % in dipropylene glycol
Luebke, William tgsc, (1988) At 10.00 % in dipropylene glycol. camphor minty phenolic herbal woody
Mosciano, Gerard P&F 18, No. 2, 38, (1993) Camphoreous, medicinal, mentholic, with a cooling green nuance
Flavor Type: Medicinal
medicinal, camphoreous, mentholic, woody
Mosciano, Gerard P&F 18, No. 2, 38, (1993) At 20.00 ppm. Medicinal, camphoreous, mentholic and woody

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 1310 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.

intraperitoneal-cat LDLo 400 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.

intravenous-mouse LD90 525 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.

intraperitoneal-rat LDLo 3500 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.

Dermal Toxicity:
subcutaneous-mouse LDLo 2200 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.

subcutaneous-rat LDLo 1700 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 665, 1978.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for dextro-camphor usage levels up to:
3.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 50.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -11.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -20.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.10000
fruit ices: -0.10000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 1.1000025.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Camphor in flavourings and other food ingredients with flavouring properties - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission
View page or View pdf

Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):464-49-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :159055
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2717
WGK Germany:1
(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Chemidplus:0000464493
EPA/NOAA CAMEO:hazardous materials
RTECS:EX1260000 for cas# 464-49-3