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4-methyl thiazole
General Material Information
| Preferred name | 4-methyl thiazole |
| Trivial Name | 4-Methylthiazole |
| Short Description | 4-methyl-1,3-thiazole |
| Formula | C4 H5 N S |
| CAS Number | 693-95-8 |
| FEMA Number | 3716 |
| Flavis Number | 15.035 |
| ECHA Number | 211-764-1 |
| FDA UNII | X8S174990R |
| Nikkaji Number | J539H |
| Beilstein Number | 0105228 |
| MDL | MFCD00005340 |
| COE Number | 11627 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| JECFA Food Flavoring | 1043 4-methylthiazole |
| FDA Patent | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm | 693-95-8 ; 4-METHYLTHIAZOLE |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
| Google Scholar | Start search |
| Google Books | Start search |
| Google Patents | Start search |
| Perfumer & Flavorists | Start search |
| EU Patents | Start search |
| PubMeb | Start search |
| NCBI | Start search |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB33116 |
| FooDB: | FDB011116 |
| YMDB (Yeast Metabolome Database): | YMDB01620 |
| Export Tariff Code: | 2934.10.0090 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 99.155853271484 |
| Specific gravity | @ 25 °C |
| Pounds per Gallon | 9.303 to 9.336 |
| Refractive Index | 1.522 to 1.526 @ 20 °C |
| Boiling Point | 133 to 134°C @ 760 mm Hg |
| Vapor Pressure | 10.031 mmHg @ 25 °C |
| Vapor Density | 3.4 |
| Flash Point TCC Value | 32.22 °C TCC |
| logP (o/w) | 0.97 |
| Solubility | |
| alcohol | Yes |
| water, 1.746e+004 mg/L @ 25 °C (est) | Yes |
Organoleptic Properties
| Odor Type: Nutty | |
| nutty, green, vegetable, tomato, alliaceous, ripe, tropical | |
| General comment | At 0.10 % in dipropylene glycol. nutty green vegetable tomato |
| Mosciano, Gerard P&F 17, No. 6, 41, (1992) | Alliaceous, ripe, nutty, vegetable, tomato with a green tropical nuance |
| Flavor Type: Green | |
| green, vegetable, meaty, alliaceous | |
| Mosciano, Gerard P&F 17, No. 6, 41, (1992) | At 10.00 ppm. Green, vegetative, meaty, with an alliaceous nuance |
| Used in bakery, meat products , soups and sauces, breakfast cereals, confectionery at 5ppm, and in dairy flavors at 3ppm. | Green |
Occurrences
| (data available) |
Potential Uses
| Applications | |
| Flavoring purposes | Bakery , Beef , Cereal , Coffee , Dairy , Filbert , Fruit tropical fruit , Green , Meat , Nut , Peanut , Soup , Tomato |
| Other purposes | Confection |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 10 - Flammable. R 22 - Harmful if swallowed. R 37/38 - Irritating to respiratory system and skin. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| gavage-mouse LD50 [sex: F] 360 ul/kg (O’Neal et al., 1978) gavage-rat LD50 [sex: M,F] 930 mg/kg (Mondino, 1981b) oral-mouse LD50 360 uL/kg SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 182, 1992. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| flavoring agents | |||
| Recommendation for 4-methyl thiazole usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.097 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.05 (μg/capita/day) | ||
| Structure Class: | II | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 13 | |||
| Click here to view publication 13 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 5.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | 5.00000 | |
| cheese: | - | 5.00000 | |
| chewing gum: | - | 5.00000 | |
| condiments / relishes: | - | 1.50000 | |
| confectionery froastings: | - | 5.00000 | |
| egg products: | - | - | |
| fats / oils: | - | 3.00000 | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | 5.00000 | |
| hard candy: | - | 5.00000 | |
| imitation dairy: | - | 2.50000 | |
| instant coffee / tea: | - | 2.00000 | |
| jams / jellies: | - | - | |
| meat products: | - | 5.00000 | |
| milk products: | - | 3.00000 | |
| nut products: | - | 5.00000 | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | 5.00000 | |
| seasonings / flavors: | - | - | |
| snack foods: | - | 5.00000 | |
| soft candy: | - | 5.00000 | |
| soups: | - | 5.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
| Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3 View page or View pdf |
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):693-95-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :12748 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 1993 |
| WGK Germany:3 |
| 4-methyl-1,3-thiazole |
| Chemidplus:0000693958 |
| RTECS:XJ5096000 for cas# 693-95-8 |