2-tert-butyl-6-methyl phenol

General Material Information

Preferred name	2-tert-butyl-6-methyl phenol
Trivial Name	2-tert-Butyl-6-methylphenol
Short Description	phenol, 2-(1,1-dimethylethyl)-6-methyl-
Formula	C11 H16 O
CAS Number	2219-82-1
ECHA Number	218-734-7
FDA UNII	LT9E3VZD1C
Nikkaji Number	J79.089C
Beilstein Number	1862362
MDL	MFCD00002239
Bio Activity Summary	External link
NMR Predictor	External link
Synonyms	2-tert- butyl-2-methylphenol 6-t- butyl-2-methylphenol 6-tert- butyl-2-methylphenol 2-tert- butyl-6-methyl-phenol 2-tert- butyl-6-methylphenol 6-tert- butyl-o-cresol o-tert- butyl-o-cresol 6-tert- butyl-ortho-cresol 6-(tert- butyl)-2-methylphenol o- cresol, 6-tert-butyl- 2-(1,1-dimethylethyl)-6-methylphenol 2-methyl-6-tert-butyl phenol phenol, 2-(1,1-dimethylethyl)-6-methyl- phenol, 2-(1,1-dimethylethyl)-6-methyl- phenol, 2-t-butyl-6-methyl- phenol, 2-tert-butyl-6-methyl- 2-tert-butyl-6-methylphenol o-Cresol, 6-tert-butyl- 2-(1,1-Dimethylethyl)-6-methylphenol 2-Methyl-6-tert-butylphenol 6-tert-Butyl-o-cresol 6-tert-Butyl-2-methylphenol 4-Hydroxy-3-methyl-5-tert-butylbenzol NSC 78461

Publications by PubMed
Formation of the N-methylpyridinium ether derivative of propofol to improve sensitivity, specificity and reproducibility of its detection in blood by liquid chromatography-mass spectrometry.
Glucuronidation of propofol and its analogs by human and rat liver microsomes.
Anaerobic biodegradability of alkylphenols and fuel oxygenates in the presence of alternative electron acceptors.
Capillary gas chromatographic assay of camphor and m-cresol in dermatological creams.
Influence of quinone methide reactivity on the alkylation of thiol and amino groups in proteins: studies utilizing amino acid and peptide models.
The enzymatic formation and chemical reactivity of quinone methides correlate with alkylphenol-induced toxicity in rat hepatocytes.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEMBL:	View
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2933.69.6050
ChemSpider:	View

BOC Sciences	Santa Cruz Biotechnology
Sigma-Aldrich: Aldrich	TCI AMERICA

Material listed in food chemical codex	No
Molecular weight	164.24772644043
Specific gravity	@ 25 °C
Pounds per Gallon
Melting Point	30 to 32°C @ 760 mm Hg
Vapor Pressure	0.053 mmHg @ 25 °C
Flash Point TCC Value	107.22 °C TCC
logP (o/w)	3.773 est
Solubility
alcohol	Yes
water, 101.3 mg/L @ 25 °C (est)	Yes
water	No

Odor Type: Leathery
phenolic, leathery, medicinal
Odor strength	high , recommend smelling in a 1.00 % solution or less
Substantivity	92 hour(s) at 10.00 % in dipropylene glycol
Luebke, William tgsc, (2001)	At 100.00 %. cresol phenolic leather medicinal

Applications	fragrance agents
Odor purposes	Citrus , Fruit , Grapefruit , Leather
Other purposes	Waxy

Preferred SDS: View
European information :
Most important hazard(s):
C - Corrosive.
R 34 - Causes burns. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 120 mg/kg BEHAVIORAL: SLEEP Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 2-tert-butyl-6-methyl phenol usage levels up to:
	0.0200 % in the fragrance concentrate.

Recommendation for 2-tert-butyl-6-methyl phenol flavor usage levels up to:
	not for flavor use.