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2-methyl butyric acid

Chemical Structure

General Material Information

Preferred name 2-methyl butyric acid
Trivial Name 2-Methylbutanoic acid
Short Description 2-methylbutyric acid
Formula C5 H10 O2
CAS Number 116-53-0
Deleted CAS Number 600-07-7
FEMA Number 2695
Flavis Number 8.046
ECHA Number 204-145-2
FDA UNII PX7ZNN5GXK
Nikkaji Number J2.000A
Beilstein Number 1720486
MDL MFCD00002669
COE Number 2002
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 255 2-methylbutyric acid
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 116-53-0 ; 2-METHYLBUTYRIC ACID
Synonyms
  • ethyl methyl acetic acid
  • ethylmethyl acetic acid
  • 2-methyl butanoic acid
  • (1)-2-methyl butyric acid
  • alpha- methyl butyric acid
  • D-2-methyl butyric acid
  • methyl butyric acid (2)
  • 2-methyl butyric acid (natural)
  • 2-methyl butyric acid natural
  • 2-methyl butyric acid synthetic
  • 2 methyl butyric acid synthetic
  • methyl butyric acid-2 natural
  • methyl ethyl acetic acid
  • methyl-2 butyric acid
  • methyl-2 butyric acid natural
  • methyl-2-butyric acid FCC
  • 2-methylbutanoic acid
  • 2-methylbutyric acid
  • nat.2-methylbutyric acid
  • nat.D-2-methylbutyric acid
  • 2-methylbutyric acid (natural)
  • 2-methylbutyric acid natural
  • 2-methylbutyric acid natural (optically active)
  • 2-methylbutyric acid pure
  • methylethyl acetic acid
  • Butanoic acid, 2-methyl-
  • Butyric acid, 2-methyl-
  • Butyric acid, α-methyl-
  • 2-Methylbutanoic acid
  • Active valeric acid
  • Ethylmethylacetic acid
  • 2-Methylbutyric acid
  • α-Methylbutyric acid
  • Methylethylacetic acid
  • α-Methyl-n-butyric acid
  • 2-Methyl-n-butyric acid
  • DL-2-Methylbutyric acid
  • (±)-2-Methylbutyric acid
  • (±)-Methylethylacetic acid
  • DL-2-Methylbutanoic acid
  • DL-α-Methylbutyric acid
  • (±)-2-Methylbutanoic acid
  • (±)-α-Methylbutyric acid
  • 2-Ethylpropanoic acid
  • NSC 7304
  • Hydroangelic acid

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

Leffingwell:Chirality or Article
2-methylbutanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:116-53-0
Pubchem (cid):8314
Pubchem (sid):134975532
Flavornet:116-53-0
Pherobase:View
Publications by Perfumer & Flavorist
Flavor Bites: 2-Methyl Butyric Acid
Publications by PubMed
In-tube Extraction and GC-MS Analysis of Volatile Components from Wild and Cultivated sea buckthorn (Hippophae rhamnoides L. ssp. Carpatica) Berry Varieties and Juice.
Aroma volatile compounds from two fresh pineapple varieties in china.
Identification of aroma-active compounds in Jiashi muskmelon juice by GC-O-MS and OAV calculation.
Identification of potent odourants in wine and brewed coffee using gas chromatography-olfactometry and comprehensive two-dimensional gas chromatography.
The compositions of volatiles and aroma-active compounds in dried omija fruits (Schisandra chinensis Baillon) according to the cultivation areas.
Composition of the essential oil of Argania spinosa (Sapotaceae) fruit pulp.
Aroma-active components of Lycii fructus (kukija).
Characterization of volatile substances in apples from Rosaceae family by headspace solid-phase microextraction followed by GC-qMS.
Contribution to the analysis of the essential oil of Helichrysum italicum (Roth) G. Don. Determination of ester bonded acids and phenols.
Essential oil composition of Pimpinella anisum L. fruits from various European countries.
Characterization of aroma compounds in apple cider using solvent-assisted flavor evaporation and headspace solid-phase microextraction.
Differentiation of aroma characteristics of pine-mushrooms (Tricholoma matsutake Sing.) of different grades using gas chromatography-olfactometry and sensory analysis.
Characterization of aroma-active compounds in raw and cooked pine-mushrooms (Tricholoma matsutake Sing.).
Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery.
Gas chromatographic-mass spectrometric analysis of essential oils from Pimpinella species gathered from Central and Northern Turkey.
Characterization of cachaça and rum aroma.
Odor-active constituents in fresh pineapple (Ananas comosus [L.] Merr.) by quantitative and sensory evaluation.
Structural and Functional Analysis of the Loading Acyltransferase from Avermectin Modular Polyketide Synthase.
Aroma compounds in Japanese sweet rice wine (Mirin) screened by aroma extract dilution analysis (AEDA).
Characterisation of the aroma profiles of different honeys and corresponding flowers using solid-phase microextraction and gas chromatography-mass spectrometry/olfactometry.
A new pollinating seed-consuming mutualism between Rheum nobile and a fly fungus gnat, Bradysia sp., involving pollinator attraction by a specific floral compound.
Biodegradation of C5-C 8 fatty acids and production of aroma volatiles by Myroides sp. ZB35 isolated from activated sludge.
Synthesis of high-quality water-soluble near-infrared-emitting CdTe quantum dots capped with 3-mercaptobutyric acid.
Possible effects of nitric oxide synthases on odor-induced behavioral changes in mice.
Aromatic profile of ciders by chemical quantitative, gas chromatography-olfactometry, and sensory analysis.
Characterization of the key aroma compounds in Bartlett pear brandies by means of the sensomics concept.
Characterization of volatile components in makgeolli, a traditional Korean rice wine, with or without pasteurization, during storage.
Relation between HLA genes, human skin volatiles and attractiveness of humans to malaria mosquitoes.
Cytotoxic (A549) and antimicrobial effects of Methylobacterium sp. isolate (ERI-135) from Nilgiris forest soil, India.
Eight new diterpenoids and two new nor-diterpenoids from the stems of Croton cascarilloides.
In-tube extraction and GC-MS analysis of volatile components from wild and cultivated sea buckthorn (Hippophae rhamnoides L. ssp. Carpatica) berry varieties and juice.
Characterization of the formation of branched short-chain fatty acid:CoAs for bitter acid biosynthesis in hop glandular trichomes.
Dehydropyrrolizidine alkaloids in two Cryptantha species: including two new open chain diesters one of which is amphoteric.
2-Methylbutyrylglycine induces lipid oxidative damage and decreases the antioxidant defenses in rat brain.
Separation and analysis of lanthanides by isotachophoresis coupled with inductively coupled plasma mass spectrometry.
Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex.
Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.
Production of volatile compounds by Lactobacillus sakei from branched chain α-keto acids.
Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry.
The compositions of volatiles and aroma-active compounds in dried omija fruits (Schisandra chinensis Baillon) according to the cultivation areas.
Identification of fruity aroma-producing compounds from Chryseobacterium sp. isolated from the Western Ghats, India.
Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces.
Host plant shifts affect a major defense enzyme in Chrysomela lapponica.
Prevalence, concentration, spoilage, and mitigation of Alicyclobacillus spp. in tropical and subtropical fruit juice concentrates.
Acid stress-mediated metabolic shift in Lactobacillus sanfranciscensis LSCE1.
FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.
Composition of the essential oil of Argania spinosa (Sapotaceae) fruit pulp.
Production of volatile metabolites by grape-associated microorganisms.
Isolation and characterization of a novel 2-sec-butylphenol-degrading bacterium Pseudomonas sp. strain MS-1.
Aroma-active components of Lycii fructus (kukija).
Kinetic modeling of methyl butanoate in shock tube.
Top note compounds of Chinese traditional bacteria-fermented soybean.
Purification and characterization of antibacterial substances produced by a marine bacterium Pseudoalteromonas haloplanktis strain.
Insertional inactivation of branched-chain alpha-keto acid dehydrogenase in Staphylococcus aureus leads to decreased branched-chain membrane fatty acid content and increased susceptibility to certain stresses.
Contribution to the analysis of the essential oil of Helichrysum italicum (Roth) G. Don. Determination of ester bonded acids and phenols.
Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy.
Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon.
Innate versus learned odour processing in the mouse olfactory bulb.
Characterization of aroma compounds in apple cider using solvent-assisted flavor evaporation and headspace solid-phase microextraction.
Pathway analysis of branched-chain ester biosynthesis in apple using deuterium labeling and enantioselective gas chromatography-mass spectrometry.
Differentiation of aroma characteristics of pine-mushrooms (Tricholoma matsutake Sing.) of different grades using gas chromatography-olfactometry and sensory analysis.
Enthalpies of formation, bond dissociation energies and reaction paths for the decomposition of model biofuels: ethyl propanoate and methyl butanoate.
Fatty acids synthesized by oral treponemes in chemically defined media.
Stereoselective biocatalytic synthesis of (S)-2-hydroxy-2-methylbutyric acid via substrate engineering by using "thio-disguised" precursors and oxynitrilase catalysis.
Absolute configuration of the creatonotines and callimorphines, two classes of arctiid-specific pyrrolizidine alkaloids.
Role of branched-chain fatty acids in pH stress tolerance in Listeria monocytogenes.
Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions.
Chemical communication in Chagas disease vectors. Source, identity, and potential function of volatiles released by the metasternal and Brindley's glands of Triatoma infestans adults.
Requirements for the formation of a chiral template.
Chiral templating of surfaces: adsorption of (S)-2-methylbutanoic acid on Pt(111) single-crystal surfaces.
Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery.
Asymmetric oxidation by Gluconobacter oxydans.
Cytotoxic clerodane diterpenes from Glossocarya calcicola.
Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors.
Pharmacological profile of 4-(2',4'-difluorobiphenyl-4-yl)-2-methylbutyric acid (deoxoflobufen).
Odor-active constituents in fresh pineapple (Ananas comosus [L.] Merr.) by quantitative and sensory evaluation.
Identification of potent odorants in different cultivars of snake fruit [Salacca zalacca (Gaert.) Voss] using gas chromatography-olfactometry.
Branched-chain fatty acid biosynthesis in a branched-chain amino acid aminotransferase mutant of Staphylococcus carnosus.
Stable isotope dilution analysis of wine fermentation products by HS-SPME-GC-MS.
2-ethylhydracrylic aciduria in short/branched-chain acyl-CoA dehydrogenase deficiency: application to diagnosis and implications for the R-pathway of isoleucine oxidation.
Role of alpha-methylacyl coenzyme A racemase in the degradation of methyl-branched alkanes by Mycobacterium sp. strain P101.
Influence of strawberry yogurt composition on aroma release.
Aroma extract dilution analysis of cv. Meeker (Rubus idaeus L.) red raspberries from Oregon and Washington.
Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands.
Total synthesis and biological evaluation of +-kalkitoxin, a cytotoxic metabolite of the cyanobacterium Lyngbya majuscula.
Enantioselective analysis of methyl-branched alcohols and acids in rhubarb (Rheum rhabarbarum L.) stalks.
Kinetics of thermophilic, anaerobic oxidation of straight and branched chain butyrate and valerate.
3-Hydroxy-2-methylbutyryl-CoA dehydrogenase deficiency.
Synthesis and evaluation of 2-amino-4-[(18)F]fluoro-2-methylbutanoic acid (FAMB): relationship of amino acid transport to tumor imaging properties of branched fluorinated amino acids.
Gas chromatographic-olfactometric characterization of aroma compounds in two types of cashew apple nectar.
Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis.
[Separation and identification of thellungianin G from the root of Pimpinella thellungiana Wolff].
Methanobrevibacter acididurans sp. nov., a novel methanogen from a sour anaerobic digester.
Cloning and inactivation of a branched-chain-amino-acid aminotransferase gene from Staphylococcus carnosus and characterization of the enzyme.
Biosynthesis of strawberry aroma compounds through amino acid metabolism.
Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis.
Correlation of long-range membrane order with temperature-dependent growth characteristics of parent and a cold-sensitive, branched-chain-fatty-acid-deficient mutant of Listeria monocytogenes.
Competitive binding of aroma compounds by beta-cyclodextrin.
The Principle of Maximum Chiral Discrimination: Chiral Recognition in Permethyl-beta-cyclodextrin.
Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases.
Reversal of LRP-associated drug resistance in colon carcinoma SW-620 cells.
Metabolism of ethyl tiglate in apple fruits leads to the formation of small amounts of (R)-ethyl 2-methylbutanoate.
Simultaneous enantioseparation of flobufen and its diastereomeric metabolites on ULMO, a Pirkle type chiral stationary phase.
Odorant molecular length: one aspect of the olfactory code.
Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species.
Biotransformation and kinetics of excretion of tert-amyl-methyl ether in humans and rats after inhalation exposure.
Enantioselective analysis of ketone bodies in patients with beta-ketothiolase deficiency, medium-chain acyl coenzyme A dehydrogenase deficiency and ketonemic vomiting.
Enantiomeric synthesis of (S)-2-methylbutanoic acid methyl ester, apple flavor, using lipases in organic solvent.
Potent aroma compounds of two red wine vinegars.
Electron paramagnetic resonance studies of the membrane fluidity of the foodborne pathogenic psychrotroph Listeria monocytogenes.
Biotransformation of [(12)C]- and [(13)C]-tert-amyl methyl ether and tert-amyl alcohol.
Metabolic pathways of flobufen-a new antirheumatic and antiarthritic drug. Interspecies comparison.
Headspace solid-phase microextraction with 1-pyrenyldiazomethane in-fibre derivatisation for analysis of faecal short-chain fatty acids.
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.
Components of the ether-insoluble resin glycoside-like fraction from Cuscuta chinensis.
Resin glycosides. XXV. Multifidins I and II, new jalapins, from the seed of Quamoclit x multifida.
Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists.
Critical role of anteiso-C15:0 fatty acid in the growth of Listeria monocytogenes at low temperatures.
Separation of the stereoisomers of the main metabolite of a non-steroidal anti-inflammatory drug, flobufen, by chiral high-performance liquid chromatography.
Chemical nature of larval osmeterial secretions of papilionid butterflies in the generaParnassius, Sericinus andPachliopta.
The gp15/400 polyprotein antigen of Brugia malayi binds fatty acids and retinoids.
Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21-methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system.
Composition of larval secretion ofChrysomela lapponica (Coleoptera, Chrysomelidae) and its dependence on host plant.
On the structure of calonyctin A, a plant growth regulator.
Activity of the AIB factor observed in prokaryotic and eukaryotic microorganisms.
Scammonins VII and VIII, two resin glycosides from Convolvulus scammonia.
Survey of conformational role of ester bonds in a cyclic depsipeptide. Study on cyclo(-L-Ala-L-Hmb-)2 by energy calculation and NMR spectroscopy.
Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis.
Sexual dimorphism in the defensive secretion of a carabid beetle.
Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity.
Propionyl-CoA condensing enzyme from Ascaris muscle mitochondria. I. Isolation and characterization of multiple forms.
Identification of hairpencil secretion from maleMamestra brassicae (L.) (Lepidoptera: Noctuidae) and electroantennogram studies.
3-Oxothiolase activities and [14C]-2-methylbutanoic acid incorporation in cultured fibroblasts from 13 cases of suspected 3-oxothiolase deficiency.
Irritant principles of the spurge family (Euphorbiaceae). XIII. Oligocyclic and macrocyclic diterpene esters from latices of some Euphorbia species utilized as source plants of honey.
Stereoselectivity in the 2-methylbutyrate incorporation into anteiso fatty acids in Bacillus subtilis mutants.
Nutritional requirements of Methanomicrobium mobile.
Effects of volatile fatty acids on propionate metabolism and gluconeogenesis in caprine hepatocytes.
Induction of peroxisomal fatty acyl-CoA oxidase and microsomal laurate hydroxylase activities by beclobric acid and two metabolites in primary cultures of rat hepatocytes.
Biosynthesis of mevinolin, a hypocholesterolemic fungal metabolite, in Aspergillus terreus.
Biochemical changes during the aerobic-anaerobic transition in Ascaris suum larvae.
Influence of oral intake of seven different antibiotics on faecal short-chain fatty acid excretion in healthy subjects.
Gas-liquid chromatographic separation of enantiomers as their diastereomeric derivatives, illustrated with 2-methylbutyric acid.
Biosynthesis of monensins A and B: the role of isoleucine.
Feedlot performance and carcass characteristics of steers fed diets containing ammonium salts of the branched-chain fatty acids and valeric acid.
Supplementation of dairy cow diets with ammonium salts of volatile fatty acids.
Synthesis of stereoisomers of 8-methyl-2-decanol and esters attractive to severalDiabrotica sp.
Use of predator odors as repellents to reduce feeding damage by herbivores : I. Snowshoe hares (Lepus americanus).
Mevinolinic acid biosynthesis by Aspergillus terreus and its relationship to fatty acid biosynthesis.
Regional differences in carboxylesterase activity between human subcutaneous and omental adipose tissue.
Constituents of mandibular and Dufour's glands of an australianPolyrhachis weaver ant.
Short-chain fatty acids in intestinal content of germfree mice monocontaminated with Escherichia coli or Clostridium difficile.
Amino acids of the Murchison meteorite: II. Five carbon acyclic primary beta-, gamma-, and delta-amino alkanoic acids.
[Metabolism of beclobrate in rat and man].
Stereoselectivity of 1-aminocyclopropanecarboxylate malonyltransferase toward stereoisomers of 1-amino-2-ethylcyclopropanecarboxylic acid.
Methyl butyrate-hydrolyzing activity of hepatic triglyceride lipase from rat post-heparin plasma.
Hydroxycarboxylic and oxocarboxylic acids in urine: products from branched-chain amino acid degradation and from ketogenesis.
Precursor directed biosynthesis of paulomycins A and B. The effects of valine, isoleucine, isobutyric acid and 2-methylbutyric acid.
Isoleucine synthesis by Clostridium sporogenes from propionate or alpha-methylbutyrate.
Microbial metabolism of 1,2-propanediol studied by the Rumen Simulation Technique (Rusitec).
Pathway of formation of branched-chain volatile fatty acids in Ascaris mitochondria.
Larval osmeterial secretions of the swallowtails (Papilio).
Adenosine 5'-triphosphate- yielding pathways of branched-chain amino acid fermentation by a marine spirochete.
Carboxylesterases-amidases.
Studies of the glycine metabolism in a patient with D-glyceric acidemia and hyperglycinemia.
Excretion pattern of branched-chain amino acid metabolites during the course of acute infections in a patient with methylmalonic acidaemia.
Biochemical studies in a patient with defects in the metabolism of acyl-CoA and sarcosine: another possible case of glutaric aciduria type II.
Inhibition of the glycine cleavage system by branched-chain amino acid metabolites.
Production of branched-chain volatile fatty acids by certain anaerobic bacteria.
Demonstration of a new mammalian isoleucine catabolic pathway yielding an Rseries of metabolites.
Growth factor requirements of Ruminococcus flavefaciens isolated from the rumen of cattle fed purified diets.
Isoleucine biosynthesis from 2-methylbutyric acid by anaerobic bacteria from the rumen.
The ultrastructure of the osmeterium and the nature of its secretion in Papilio larvae (lepidoptera).
Volatile fatty acid requirements of cellulolytic rumen bacteria.
Characterization of several bovine rumen bacteria isolated with a xylan medium.
Defensive Secretion of a Caterpillar (Papilio).

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C18319
HMDB (The Human Metabolome Database):HMDB02176
FooDB:FDB008135
YMDB (Yeast Metabolome Database):YMDB01587
Export Tariff Code:2915.60.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 102.13310241699
Specific gravity @ 25 °C
Pounds per Gallon 7.73 to 7.797
Refractive Index 1.401 to 1.408 @ 20 °C
Boiling Point 176 to 177°C @ 760 mm Hg
Vapor Pressure 0.554 mmHg @ 25 °C
Vapor Density 3.5
Flash Point TCC Value 73.89 °C TCC
logP (o/w) 1.18
Shelf life 6 months (or longer if stored properly.)
Storage notes Refrigerate in tightly sealed containers.
Solubility
alcohol Yes
propylene glycol Yes
water, 45000 mg/L @ 20 °C (exp) Yes
water No

Organoleptic Properties

Odor Type: Acidic
pungent, acidic, cheesy roquefort cheese, cheesy, fruity, dirty, fermented
Odor strength medium , recommend smelling in a 10.00 % solution or less
Substantivity 244 hour(s) at 100.00 %
Luebke, William tgsc, (1989) At 10.00 % in propylene glycol. pungent acid roquefort cheese
Mosciano, Gerard P&F 16, No. 2, 49, (1991) Acidic, fruity, dirty, cheesey with a fermented nuance
Flavor Type: Fruity
fruity, dirty, acidic, dairy, buttery, cheesy
Mosciano, Gerard P&F 16, No. 2, 49, (1991) At 10.00 ppm. Fruity, dirty, acidic with a dairy buttery and cheesey nuance
Used in cream cheese and chocolate flavors. Creamy
Useful in: brown cocoa, brown coffee, dairy, fruity red, fruity yellow, fruity tropical, fruity others. Acidic taste, becoming fruity at concentrations below 10 ppm
General comment Fruity, sour, cheesy in dilution; acidic, sweaty, berry-like

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
C - Corrosive.
R 21/22 - Harmful in contact with skin and if swallowed.
R 34 - Causes burns.
S 01/02 - Keep locked up and out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 27 - Take off immediately all contaminated clothing.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3200 mg/kg
ATDAEI
1,171,1992

oral-rat LD50 1870 uL/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS MUSCULOSKELETAL: OTHER CHANGES
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 171, 1992.

Dermal Toxicity:
skin-rabbit LD50 10 ml/kg
ATDAEI
1,171,1992

skin-rabbit LD50 1460 uL/kg
BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: OTHER CHANGES
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 171, 1992.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 2-methyl butyric acid usage levels up to:
0.0200 % in the fragrance concentrate.
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -0.50000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -3.00000
fruit ices: -3.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 1, Revision 1 (FGE.01Rev 1): Branched-chain aliphatic saturated aldehydes, carboxylic acids and related esters of primary alcohols and branched-chain carboxylic acids from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission
View page or View pdf

Flavouring Group Evaluation 47, (FGE.47)[1] - Bicyclic secondary alcohols, ketones and related esters from chemical group 8 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Flavouring Group Evaluation 01 Rev2 (FGE.01 Rev2): Branched-chain aliphatic saturated aldehydes, carboxylic acids and related esters of primary alcohols and branched-chain carboxylic acids from chemical groups 1 and 2
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):116-53-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8314
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3265
WGK Germany:1
2-methylbutanoic acid
Chemidplus:0000116530
RTECS:EK7897000 for cas# 116-53-0