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sodium salicylate

Chemical Structure

General Material Information

Preferred name sodium salicylate
Trivial Name Sodium salicylate
Short Description 2-hydroxybenzoic acid, monosodium salt
Formula C7 H5 Na O3
CAS Number 54-21-7
Deleted CAS Number 18495-69-7
ECHA Number 200-198-0
FDA UNII WIQ1H85SYP
Beilstein Number 3732792
MDL MFCD00002440
Bio Activity Summary External link
NMR Predictor External link
Synonyms
  • alysine
  • ardall
  • aroall
  • benzoic acid, 2-hydroxy-, monosodium salt
  • benzoic acid, 2-hydroxy-, sodium salt (1:1)
  • camporisin
  • enterosalicyl
  • enterosalil
  • entrosalyl
  • glutosalyl
  • 2-hydroxybenzoic acid monosodium salt
  • o- hydroxybenzoic acid monosodium salt
  • 2-hydroxybenzoic acid sodium salt
  • 2-hydroxybenzoic acid, monosodium salt
  • idocyl novum
  • kerasalicyl
  • kerosal
  • magsalyl
  • nadisal
  • pabalate
  • parbocyl-rev
  • neo- salicyl
  • salicylic acid monosodium salt
  • salicylic acid sodium salt
  • salicylic acid, monosodium salt
  • salicylic acid, sodium salt
  • salisod
  • salsonin
  • mono sodium 2-hydroxybenzoate
  • sodium o-hydroxybenzoate
  • sodium ortho-hydroxybenzoate
  • mono sodium salicylate
  • sodium salicylate USP
  • sodium;2-hydroxybenzoate
  • sodiumsalicylate
  • Clin
  • Sodium salicylate (NaO3C7H5)
  • Monosodium salicylate
  • Neo-Salicyl
  • Sodium 2-hydroxybenzoate
  • o-Hydroxybenzoic acid monosodium salt
  • Idocyl
  • Saliject
  • NaSal 31821-45
  • MeSH ID: D012980

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Literature & References

sodium;2-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:54-21-7
Pubchem (cid):16760658
Pubchem (sid):134971649
Publications by PubMed
Assessment of ABCG2-mediated transport of xenobiotics across the blood-milk barrier of dairy animals using a new MDCKII in vitro model.
[New drugs for horses and production animals in 2011].
Effective induction of oral anaphylaxis to ovalbumin in mice sensitized by feeding of the antigen with aid of oil emulsion and salicylate.
Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.
Food-derived bioactives as potential regulators of the IL-12/IL-23 pathway implicated in inflammatory bowel diseases.
Effect of Hofmeister anions on micellization and micellar growth of the surfactant cetylpyridinium chloride.
Linear-to-branched micelles transition: a rheometry and diffusing wave spectroscopy (DWS) study.
Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli.
Ultrasound velocimetry in a shear-thickening wormlike micellar solution: evidence for the coexistence of radial and vorticity shear bands.
Ion chromatographic determination of organic acids in food samples using a permanent coating graphite carbon column.
Efflux pump activity in fluoroquinolone and tetracycline resistant Salmonella and E. coli implicated in reduced susceptibility to household antimicrobial cleaning agents.
Can high-performance liquid chromatography coupled with fluorescence detection under all conditions be regarded as a sufficiently conclusive confirmatory method for B-group substances?
Salicylate activity. 2. Potentiation of atrazine.
Salicylate activity. 1. Protection of plants from paraquat injury.
Stress driven shear bands and the effect of confinement on their structures--a rheological, flow visualization, and Rheo-SALS study.
Sodium salicylate attenuates lipopolysaccharide (LPS)-induced adipsia, but not hypophagia, in broiler chickens.
Environmental regulation of Campylobacter jejuni major outer membrane protein porin expression in Escherichia coli monitored by using green fluorescent protein.
Rapid and specific detection of hydroxyl radical using an ultraweak chemiluminescence analyzer and a low-level chemiluminescence emitter: application to hydroxyl radical-scavenging ability of aqueous extracts of Food constituents.
Inhibitory effect of sodium salicylate on nitric oxide production from TM4 sertoli cells.
Postnatal evolution of supernumerary ribs in rats after a single administration of sodium salicylate.
Induction of supernumerary ribs with sodium salicylate.
Behavioral model of chronic tinnitus in rats.
Immune cytokines and regulation of body temperature, food intake and cellular immunity.
Chemically induced alterations in maternal homeostasis and histology of conceptus: their etiologic significance in rat fetal anomalies.
Acute toxicity testing in the nonlethal dose range: a new approach.
Effects of dietary sodium selenite supplementation on salicylate-induced embryo- and fetotoxicity in the rat.
The induction of supernumerary ribs in rodents: role of the maternal stress.
[Adverse reactions to food preservatives].
The role of fever in appetite suppression after endotoxin administration.
Sodium salicylate and aspirin disease.
Strategy for the assessment of neurobehavioral consequences of environmental factors.
Histological changes in the skeletal elements of developing rat foetuses following treatment with sodium salicylate.
Effect of sodium salicylate on the food and oxygen consumption of rats.
THE INFLUENCE OF BILE ON METABOLISM.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07587
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 160.1042175293
Vapor Pressure 4.4E-5 mmHg @ 25 °C
Flash Point TCC Value 144.5 °C TCC
logP (o/w) 2.061 est
Solubility
water, 1.25E+05 mg/L @ 25 °C (exp) Yes
water, 1e+006 mg/L @ 25 °C (est) Yes

Potential Uses

Applications
Other purposes Preservatives
Cosmetic purposes Denaturants , Preservatives

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 562 mg/kg
BEHAVIORAL: ANALGESIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.

intraperitoneal-dog LDLo 990 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

oral-dog LDLo 450 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

intraperitoneal-guinea pig LDLo 900 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

oral-human LDLo 700 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
New England Journal of Medicine. Vol. 232, Pg. 617, 1945.

intramuscular-mouse LD50 760 mg/kg
Acta Paediatrica Scandinavica. Vol. 59, Pg. 517, 1970.

intraperitoneal-mouse LD50 500 mg/kg
Strahlentherapie. Vol. 127, Pg. 245, 1965.

intravenous-mouse LD50 500 mg/kg
British Patent Document. Vol. #1009195

oral-mouse LD50 540 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.

intravenous-rabbit LD50 415 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.

oral-rabbit LD50 1700 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 205, 1947.

intraperitoneal-rat LD50 542 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.

oral-rat LD50 930 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

Dermal Toxicity:
subcutaneous-dog LDLo 200 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

subcutaneous-frog LDLo 250 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

subcutaneous-guinea pig LDLo 800 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

subcutaneous-mouse LD50 550 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
preservatives
Recommendation for sodium salicylate usage levels up to:
not for fragrance use.
Recommendation for sodium salicylate flavor usage levels up to:
not for flavor use.

Safety references

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):54-21-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16760658
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
sodium;2-hydroxybenzoate
Chemidplus:0000054217
RTECS:VO5075000 for cas# 54-21-7