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dextro,laevo-homatropine hydrobromide

Chemical Structure

General Material Information

Preferred name dextro,laevo-homatropine hydrobromide
Trivial Name Homatropine hydrobromide
Short Description homatropine DL- hydrobromide
Formula C16 H22 Br N O3
CAS Number 51-56-9
ECHA Number 200-105-3
FDA UNII BEW7469QZ0
MDL MFCD00012676
Bio Activity Summary External link
NMR Predictor External link
Synonyms
  • (+-)-homatropine bromide
  • (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
  • (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
  • 1alphaH,5alphaH- tropan-3alpha-ol mandelate (ester) hydrobromide
  • benzeneacetic acid, alpha-hydroxy-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide
  • benzeneacetic acid, alpha-hydroxy-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide (1:1)
  • benzeneacetic acid, alpha-hydroxy-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, HBr, endo-(+-)
  • benzeneacetic acid, alpha-hydroxy-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide, endo-(+-)-
  • homatropine (bromhydrate d')
  • homatropine DL-hydrobromide
  • dextro, laevo-homatropine hydrobromid
  • Benzeneacetic acid, α-hydroxy-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide (1:1)
  • 1αH,5αH-Tropan-3α-ol, mandelate (ester), hydrobromide
  • Benzeneacetic acid, α-hydroxy-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide, endo-
  • Benzeneacetic acid, α-hydroxy-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide
  • Homatropine hydrobromide
  • Mandelic acid tropine ester hydrobromide
  • (±)-Homatropine bromide
  • Homatropine bromide
  • Isopto Homatropine

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Literature & References

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5821
Pubchem (sid):134972439
Publications by PubMed
The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults.
Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE.
Interference of mandelic acid with the determination of homatropine hydrobromide by second-order derivative spectroscopy.
Use of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomy.
Determination of homatropine hydrobromide in eye drops by second-order derivative spectroscopy.
[Correction of the symptoms of late substance withdrawal syndrome by intra-conjunctival administration of 5% homatropine solution (preliminary report)].
An evaluation of the effectiveness of intramuscular atropine or homatropine eyedrops in preventing the effects of physostigmine eyedrops on human vision.
Effect of urea on the activity of certain ophthalmic drugs in man.
Memo on medications: atropine sulfate and homatropine hydrobromide: common mydriatic/cycloplegic agents.
Relapsing polychondritis in a Latin American man.
[Photometric determination of homatropine hydrobromide in eyedrops].
[Cycloplegia and residual accommodation (author's transl)].
[Homatropine hydrobromide].
Stability determination of homatropine hydrobromide by direct cerimetric titration.
HOMATROPINE HYDROBROMIDE. EFFECT OF TOPICAL ADMINISTRATION UPON THE INTRAOCULAR PRESSURE AND AQUEOUS FACILITY VALUES OF NORMAL AND CHRONIC SIMPLE GLAUCOMATOUS EYES.
[Use of a 4 per cent solution of homatropine hydrobromide for the determination of refraction in young patients].
Ophthalmic vehicles: the effect of methylcellulose on the penetration of homatropine hydrobromide through the cornea.
Effects of atropine sulfate, methylatropine nitrate (metropine) and homatropine hydrobromide on adult human eyes.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.99.9700
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 356.25994873047
Flash Point TCC Value N/a
Solubility
water, 1.49E+05 mg/L @ 25 °C (exp) Yes
water, 2.042e+004 mg/L @ 25 °C (est) Yes

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 107 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 96, Pg. 1, 1949.

intraperitoneal-rat LD50 154 mg/kg
Drugs in Japan Vol. 6, Pg. 789, 1982.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
pharmaceuticals / chemical synthisis
Recommendation for dextro,laevo-homatropine hydrobromide usage levels up to:
not for fragrance use.
Recommendation for dextro,laevo-homatropine hydrobromide flavor usage levels up to:
not for flavor use.

Safety references

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):51-56-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5821
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
Chemidplus:0000051569
RTECS:YM5602000 for cas# 51-56-9