formaldehyde

General Material Information

Preferred name	formaldehyde
Trivial Name	Formaldehyde
Short Description	methaldehyde
Formula	C H2 O
CAS Number	50-00-0
ECHA Number	200-001-8
FDA UNII	1HG84L3525
Nikkaji Number	J2.294B
Beilstein Number	1209228
MDL	MFCD00003274
xLogP3-AA	1.20 (est)
Bio Activity Summary	External link
NMR Predictor	External link
FDA Mainterm	50-00-0 ; FORMALDEHYDE
Synonyms	formalin formic aldehyde formol methaldehyde methanal methyl aldehyde paraform BFV Fannoform Formalith Fyde Methylene oxide Oxomethane Oxymethylene Superlysoform Lysoform Morbicid Floguard 1015 FM 282 F-gen Fordor NSC 298885 Formalin LM Optilyse Formalin Taisei Formaldehyde-12C FS 850A Sigma-F 8775 MeSH ID: D005557

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Literature & References

	formaldehyde
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	50-00-0
Pubchem (cid):	712
Pubchem (sid):	134970847
Pherobase:	View

Publications by Info
Formaldehyde
Publications by PubMed
Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies.
The influence of douchi starter cultures on the composition of extractive components, microbiological activity, and sensory properties of fermented fish pastes.
Thermal generation of 3-amino-4,5-dimethylfuran-2(5H)-one, the postulated precursor of sotolone, from amino acid model systems containing glyoxylic and pyruvic acids.
A liquid chromatographic method optimization for the assessment of low and high molar mass carbonyl compounds in wines.
Analysis of selected carbonyl oxidation products in wine by liquid chromatography with diode array detection.
Toxicologic evaluation of licorice extract as a cigarette ingredient.
Carcass, sensory, and adipose tissue traits of Brangus steers fed casein-formaldehyde-protected starch and/or canola lipid.
Effects of treatment of whole fat soybeans or soy flour with formaldehyde to protect the polyunsaturated fatty acids from biohydrogenation in the rumen.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
FDA Indirect Additives used in Food Contact Substances:	View
CHEBI:	View
CHEMBL:	View
Metabolomics Database:	Search
UM BBD:	Search
KEGG (GenomeNet):	C00067
HMDB (The Human Metabolome Database):	HMDB01426
FooDB:	FDB009445
YMDB (Yeast Metabolome Database):	YMDB00321
Export Tariff Code:	2912.11.0000
FDA Listing of Food Additive Status:	View
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
Formulations/Preparations: •pure formaldehyde is not avail commercially because of its tendency to polymerize. it is sold as aqueous solutions containing from 37% to 50% formaldehyde by wt & varying amounts of methanol. •marketed under the trade name formcel, soln in methanol, n-butanol, and isobutanol. ... •aq formaldehyde, known as formalin, is usually 37% by weight of formaldehyde, though more concn soln are available. formalin is the general-purpose formaldehyde of commerce supplied unstabilized or methanol-stabilized. formaldehyde may also exist in the form of the cyclic trimer trioxane. this is a fairly stable cmpd that does not easily release formaldehyde. ... •grade: aqueous solutions: 37%, 44%, 50% inhibited (with varying percentages of methanol) or stabilized or unstabilized (methanol-free), also available in solution in n-butanol, ethanol, or urea; usp (37% aqueous solution containing methanol). •soluble concentrate; hot fogging concentrate •formaldehyde is available in the united states as as paraformaldehyde. paraformaldehyde is available as a powdered or flaked product that contains the equivalent of 90-93% formaldehyde, a maximum of 9% water, and a maximum of 0.03% acidity as formic acid. it is readily soluble in hot water with the evolution of formaldehyde vapors ... •formalin consists of an aqueous solution of formaldehyde, usually containing about 37% formaldehyde and 12-15% methanol. formalin

Suppliers

ECSA Chemicals	Kraft Chemical
Krunal Group	Penta International
Sigma-Aldrich: Sigma	Wedor Corporation
Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	30.026140213013
Specific gravity	@ 25 °C
Pounds per Gallon
Vapor Pressure	3463.820068 mmHg @ 25 °C
Flash Point TCC Value	56.11 °C TCC
logP (o/w)	0.35
Solubility
water, 400000 mg/L @ 20 °C (exp)	Yes

Occurrences

Potential Uses

Applications	food-contact surface of paper and paperboard
Other purposes	Preservatives
Cosmetic purposes	Preservatives

Safety Information

Safety information

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 30 mg/kg BLOOD: OTHER CHANGES Acta Pharmacologica et Toxicologica. Vol. 8, Pg. 275, 1952. intravenous-dog LDLo 70 mg/kg International Polymer Science and Technology. Vol. 3, Pg. 93, 1976. parenteral-frog LDLo 800 ug/kg International Polymer Science and Technology. Vol. 3, Pg. 93, 1976. oral-guinea pig LD50 260 mg/kg Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. unreported-man LDLo 477 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-man TDLo 643 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH Japanese Journal of Toxicology. Vol. 4, Pg. 261, 1991. oral-man TDLo 646 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: GASTRITIS Japanese Journal of Toxicology. Vol. 4, Pg. 261, 1991. oral-mouse LD50 42 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD National Technical Information Service. Vol. AD-A125-539 intraperitoneal-mouse LDLo 16 mg/kg Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972. intravenous-rabbit LDLo 48 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955. intravenous-rat LD50 87 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 221, Pg. 166, 1954. oral-rat LD50 100 mg/kg Food and Chemical Toxicology. Vol. 26, Pg. 447, 1988.
Dermal Toxicity:
subcutaneous-dog LDLo 350 mg/kg International Polymer Science and Technology. Vol. 3, Pg. 93, 1976. subcutaneous-mouse LD50 300 mg/kg LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950. skin-rabbit LD50 270 uL/kg Union Carbide Data Sheet. Vol. 4/21/1967 subcutaneous-rabbit LDLo 240 mg/kg JAMA, Journal of the American Medical Association. Vol. 62, Pg. 984, 1914. subcutaneous-rat LD50 420 mg/kg LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA Acta Pharmacologica et Toxicologica. Vol. 6, Pg. 299, 1950.
Inhalation Toxicity:
inhalation-cat LCLo 400 mg/m3/2H "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 69, 1982. inhalation-human TCLo 17 mg/m3/30M SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES JAMA, Journal of the American Medical Association. Vol. 165, Pg. 1908, 1957. inhalation-man TCLo 300 ug/m3 BEHAVIORAL: AGGRESSION SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 12(7), Pg. 20, 1968. inhalation-mouse LC50 454000 mg/m3/4H Current Toxicology. Vol. 1, Pg. 47, 1993. inhalation-rat LC50 203 mg/m3 BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 55, 1974.

Safety in use information

Category:
food-contact surface of paper and paperboard
Recommendation for formaldehyde usage levels up to:
	not for fragrance use.

Recommendation for formaldehyde flavor usage levels up to:
	not for flavor use.
NOEL (No Observed Effect Level):		15 (mg/kg bw per day)

Safety references

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
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Report of ESCO WG on non-plastic Food Contact Materials
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to use of formaldehyde as a preservative during the manufacture and preparation of food additives
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Reasoned opinion on the modification of the existing MRLs for metaldehyde in certain legume vegetables and pulses
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Scientific Opinion on the re-evaluation of hexamethylene tetramine (E 239) as a food additive
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Scientific Opinion on the safety and efficacy of formaldehyde as a feed hygiene substance in feed for pigs and poultry
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EFSA scientific advice to EC on accumulating formaldehyde in GM soybeans
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EPI System: View

EPA-Iris:IRIS

ClinicalTrials.gov:search

Daily Med:search

NIOSH International Chemical Safety Cards:search

NIOSH Pocket Guide:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search