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procaine hydrochloride
General Material Information
| Preferred name | procaine hydrochloride |
| Trivial Name | Procaine hydrochloride |
| Short Description | 4-aminobenzoic acid 2-(diethylamino)ethyl ester monohydrochloride |
| Formula | C13 H21 Cl N2 O2 |
| CAS Number | 51-05-8 |
| Deleted CAS Number | 12663-50-2 |
| ECHA Number | 200-077-2 |
| FDA UNII | 95URV01IDQ |
| Beilstein Number | 3917802 |
| MDL | MFCD00013000 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| Synonyms |
|
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Literature & References
| 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 51-05-8 |
| Pubchem (cid): | 5795 |
| Pubchem (sid): | 134972096 |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07894 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2922.49.3700 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Suppliers
| BOC Sciences | Glentham Life Sciences |
| Santa Cruz Biotechnology | Sigma-Aldrich: Sigma |
| TCI AMERICA |
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 272.77478027344 |
| Vapor Pressure | 9.0E-6 mmHg @ 25 °C |
| Flash Point TCC Value | 179.8 °C TCC |
| logP (o/w) | 2.364 est |
| Solubility | |
| water, 9.404e+005 mg/L @ 25 °C (est) | Yes |
Safety Information
Safety information
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| intravenous-cat LDLo 10 mg/kg CARDIAC: CHANGE IN RATE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 385, 1916. intravenous-dog LD50 63 mg/kg CARDIAC: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Dental Research. Vol. 20, Pg. 425, 1941. intravenous-guinea pig LD50 51 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. intramuscular-mouse LD50 500 mg/kg Therapie. Vol. 9, Pg. 332, 1954. intraperitoneal-mouse LD50 165 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 793, 1976. intravenous-mouse LD50 33 mg/kg Anesthesia Progress. Vol. 36, Pg. 79, 1989. oral-mouse LD50 175 mg/kg Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951. parenteral-mouse LD50 192 mg/kg BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA Antibiotics and Chemotherapy Vol. 4, Pg. 633, 1954. intravenous-rabbit LD50 43 mg/kg Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979. unreported-rabbit LD50 41 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1957, 1974. intraperitoneal-rat LD50 160 mg/kg Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979. intravenous-rat LD50 38 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Anesthesiology. Vol. 3, Pg. 398, 1942. oral-rat LD50 200 mg/kg Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951. unreported-rat LD50 150 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1012, 1967. | |
| Dermal Toxicity: | |
| subcutaneous-guinea pig LD50 407 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948. subcutaneous-mammal (species unspecified) LD50 630 mg/kg Ceska a Slovenska Farmacie. Vol. 44, Pg. 210, 1995. subcutaneous-mouse LD50 339 mg/kg Bollettino Chimico Farmaceutico. Vol. 107, Pg. 310, 1968. subcutaneous-rabbit LD50 687 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948. subcutaneous-rat LD50 597 mg/kg Pharmaceutical Archives. Vol. 11, Pg. 81, 1940. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| pharmaceuticals / chemical synthisis | |||
| Recommendation for procaine hydrochloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for procaine hydrochloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety references
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):51-05-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5795 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride |
| Chemidplus:0000051058 |
| RTECS:DG2275000 for cas# 51-05-8 |