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hydroxyproline

Chemical Structure

General Material Information

Preferred name hydroxyproline
Trivial Name L-Hydroxyproline
Short Description L-proline, 4-hydroxy-, (4S)-
Formula C5 H9 N O3
CAS Number 51-35-4
ECHA Number 200-091-9
FDA UNII RMB44WO89X
Nikkaji Number J191.775G
Beilstein Number 081441
MDL MFCD00064320
xLogP3-AA -3.30 (est)
Bio Activity Summary External link
NMR Predictor External link
FDA Mainterm 51-35-4 ; L-HYDROXYPROLINE
Synonyms
  • (2S,4S)-(-)-4-hydroxy-2-pyrrolidinecarboxylic acid
  • (2S,4S)-4-hydroxy-2-pyrrolidinecarboxylic acid
  • (4S)-4-hydroxy-L-prolin
  • (4S)-4-hydroxy-L-proline
  • trans-4-hydroxy-laevo-proline
  • L- hydroxyproline
  • L-4-hydroxyproline
  • laevo-4-hydroxyproline
  • (2S,4S)-(-)-4-hydroxypyrrolidine-2-carboxylic acid
  • (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
  • L- proline, 4-hydroxy-, (4S)-
  • (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
  • L-Proline, 4-hydroxy-, (4R)-
  • Proline, 4-hydroxy-, L-
  • L-Proline, 4-hydroxy-, trans-
  • (4R)-4-Hydroxy-L-proline
  • Hydroxy-L-proline
  • 4-Hydroxyproline
  • 4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic acid
  • Hypro
  • δ-Hydroxyproline
  • 4-Hydroxy-L-proline
  • trans-4-Hydroxyproline
  • trans-4-Hydroxy-L-proline
  • trans-L-Hydroxyproline
  • 4-trans-Hydroxy-L-proline
  • L-4-Hydroxyproline
  • Ls-Hydroxyproline
  • (2S,4R)-(-)-4-Hydroxyproline
  • L-Hydroxyproline
  • L-trans-4-Hydroxyproline
  • (R)-4-Hydroxy-(S)-proline
  • (S)-Hydroxyproline
  • L-Hypro
  • (-)-4-Hydroxy-2-pyrrolidinecarboxylic acid
  • trans-L-4-Hydroxyproline
  • (R)-4-Hydroxy-L-proline
  • Proline, 4-hydroxy-
  • (2S,4R)-4-Hydroxyproline
  • NSC 46704
  • 4-Hydroxy-(S)-proline
  • 4(R)-Hydroxyproline
  • (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
  • (4R,2S)-Hydroxyproline
  • trans-(2S,4R)-4-Hydroxy-L-proline
  • MeSH ID: D006909

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:51-35-4
Pubchem (cid):440015
Pubchem (sid):134972273
Publications by J-Stage
Increasing Effect of an Oral Intake of L-Hydroxyproline on the Soluble Collagen Content of Skin and Collagen Fragments in Rat Serum

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C01157
HMDB (The Human Metabolome Database):HMDB00725
YMDB (Yeast Metabolome Database):YMDB00723
Export Tariff Code:2933.99.9701
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 131.13133239746
Boiling Point 355 to 356°C @ 760 mm Hg
Vapor Pressure 1.0E-6 mmHg @ 25 °C
Flash Point TCC Value 168.6 °C TCC
logP (o/w) -0.35 est
Solubility
water, 361000 mg/L @ 25 °C (exp) Yes

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
special dietary and nutritional additives
Recommendation for hydroxyproline usage levels up to:
not for fragrance use.
Recommendation for hydroxyproline flavor usage levels up to:
not for flavor use.

Safety references

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):51-35-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :440015
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
Chemidplus:0000051354