pyridoxal 5’-phosphate

General Material Information

Preferred name	pyridoxal 5’-phosphate
Trivial Name	Pyridoxal 5′-phosphate
Short Description	isonicotinaldehyde, 3-hydroxy-5- (hydroxymethyl)-2-methyl-, 5-(dihydrogen phosphate)
Formula	C8 H10 N O6 P
CAS Number	54-47-7
Deleted CAS Number	52064-48-9
ECHA Number	200-208-3
FDA UNII	F06SGE49M6
Nikkaji Number	J10.690I
Beilstein Number	234749
MDL	MFCD00006333
xLogP3-AA	-1.10 (est)
Bio Activity Summary	External link
NMR Predictor	External link
Synonyms	aderoxal apolon B6 coenzyme B6 (4-formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl dihydrogen phosphate 4-formyl-5-hydroxy-6-methyl-pyridin-3-yl)methoxyphosphonic acid (4-formyl-5-hydroxy-6-methyl(3-pyridyl))methyl dihydrogen phosphate (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxyphosphonic acid (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hexermin P 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehyde 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate iso nicotinaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl-, 5-(dihydrogen phosphate) phosphate, pyridoxal phosphopyridoxal phosphopyridoxal coenzyme phosphoric acid mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester phosphoridoxal coenzyme 4-pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)- 4-pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[ (phosphonooxy)methyl]- 4-pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]- pyridoxal 5 phosphate pyridoxal 5-monophosphoric acid ester pyridoxal 5-phosphate pyridoxal 5'-(dihydrogen phosphate) pyridoxal monophosphate pyridoxal phosphate pyridoxal phosphate (6CI) pyridoxal-5-monophosphate pyridoxal-5-phosphate pyridoxal-5'-phosphate pyridoxal-5P pyridoxal-P pyridoxal, 5-(dihydrogen phosphate) (8CI) pyridoxal, 5-(dihydrogenphosphate) pyridoxaldehyde phosphate pyridoxalphosphate sechvitan vitahexin P vitahexin-P vitamin B6 phosphate 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]- Pyridoxal, 5-(dihydrogen phosphate) 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde Codecarboxylase 2-Methyl-3-hydroxy-4-formyl-5-pyridylmethylphosphoric acid PLP Pyridoxal 5′-phosphate Vitamin B6 phosphate (ester) Pyridoxal P PAL-P 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate Pyromijin Vitazechs Pyridoxyl phosphate Hairoxal Hiadelon Biosechs Hi-Pyridoxin Piodel Pydoxal NSC 82388 [(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate MeSH ID: D011732

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Literature & References

	(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	54-47-7
Pubchem (cid):	1051
Pubchem (sid):	134971793

Publications by PubMed
Engineering Saccharomyces cerevisiae to release 3-Mercaptohexan-1-ol during fermentation through overexpression of an S. cerevisiae Gene, STR3, for improvement of wine aroma.
Short communication: empirical and mechanistic evidence for the role of pyridoxal-5'-phosphate in the generation of methanethiol from methionine.
Characterization and role of the branched-chain aminotransferase (BcaT) isolated from Lactococcus lactis subsp. cremoris NCDO 763.
Purification and characterization of L-methionine gamma-lyase from brevibacterium linens BL2
An aminotransferase from Lactococcus lactis initiates conversion of amino acids to cheese flavor compounds.
Characterization of a pyridoxal-5'-phosphate-dependent l-lysine decarboxylase/oxidase from Burkholderia sp. AIU 395.
Characterization of a glutamate decarboxylase (GAD) gene from Lactobacillus zymae.
Neuroadaptations in the striatal proteome of the rat following prolonged excessive sucrose intake.
Targeting Cystalysin, a Virulence Factor of Treponema denticola-Supported Periodontitis.
The biomarker-based validity of a food frequency questionnaire to assess the intake status of folate, pyridoxine and cobalamin among Iranian primary breast cancer patients.
Submerged fermentation of Lactobacillus rhamnosus YS9 for Î³-aminobutyric acid (GABA) production.
Clinical use of cyclooxygenase inhibitors impairs vitamin B-6 metabolism.
Cloning Rosa hybrid phenylacetaldehyde synthase for the production of 2-phenylethanol in a whole cell Escherichia coli system.
Utilization of barley or wheat bran to bioconvert glutamate to Î³-aminobutyric acid (GABA).
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Campylobacter jejuni pdxA affects flagellum-mediated motility to alter host colonization.
A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites.
Photooxidation of other B-vitamins as sensitized by riboflavin.
Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects.
Prediagnostic plasma vitamin B6 (pyridoxal 5'-phosphate) and survival in patients with colorectal cancer.
A medicinal food provides food for thought in managing diabetic neuropathy.
Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.
Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.
Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements.
Enzymatic synthesis oF L-tryptophan from D,L-2-amino-delta2-thiazoline-4-carboxylic acid and indole by Pseudomonas sp. TS1138 L-2-amino-delta2-thiazoline-4-carboxylic acid hydrolase, S-carbamyl-L-cysteine amidohydrolase, and Escherichia coli L-tryptophanase.
Biogenic amines in italian pecorino cheese.
All-enzymatic HPLC method for determination of individual and total contents of vitamin B(6) in foods.
Serine Hydroxymethyltransferase from the Cold Adapted Microorganism Psychromonas ingrahamii: A Low Temperature Active Enzyme with Broad Substrate Specificity.
Tyramine and phenylethylamine biosynthesis by food bacteria.
Type 1 diabetes impairs vitamin B(6) metabolism at an early stage of women's adulthood.
Biomedical aspects of pyridoxal 5'-phosphate availability.
Individual vitamin B6 contents in selected Japanese sushi toppings.
Endo-inulinase stabilization by pyridoxal phosphate modification: a kinetics, thermodynamics, and simulation approach.
Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women.
Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population.
Oral clefts and maternal biomarkers of folate-dependent one-carbon metabolism in Utah.
Long-term prednisolone treatments increase bioactive vitamin B6 synthesis in vivo.
Vitamin B(6) salvage enzymes: mechanism, structure and regulation.
Purinergic mechanisms of lateral parabrachial nucleus facilitate sodium depletion-induced NaCl intake.
Production of gamma-aminobutyric acid by Lactobacillus brevis NCL912 using fed-batch fermentation.
Dietary intake of vitamin B-6, plasma pyridoxal 5'-phosphate, and homocysteine in Puerto Rican adults.
Lipid glycation and protein glycation in diabetes and atherosclerosis.
Purification and biochemical characterisation of a novel glutamate decarboxylase from rice bran.
Use of sourdough fermentation and pseudo-cereals and leguminous flours for the making of a functional bread enriched of gamma-aminobutyric acid (GABA).
Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes.
Identification of rose phenylacetaldehyde synthase by functional complementation in yeast.
Plasma vitamin B(6) and risk of myocardial infarction in women.
Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women.
Induction of the histidine decarboxylase genes of Photobacterium damselae subsp. damselae (formally P. histaminum) at low pH.
Antidipsogenic effects of central adenosine-5'-triphosphate.
Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.
Age-related alterations of B-group vitamin contents in urine, blood and liver from rats.
Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis.
Vitamin B6 is associated with depressive symptomatology in Massachusetts elders.
Alteration of cholinergic, purinergic and sensory neurotransmission in the mouse colon of food allergy model.
Updated molecular knowledge about histamine biosynthesis by bacteria.
Public health significance of elevated homocysteine.
Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation.
Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage.
Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly.
Simultaneous determination of water-soluble vitamins in selected food matrices by liquid chromatography/electrospray ionization tandem mass spectrometry.
Analysis of amadori-glycated phosphatidylethanolamine in the plasma of healthy subjects and diabetic patients by liquid chromatography-tandem mass spectrometry.
Glycation of plasma lipoprotein lipid membrane and screening for lipid glycation inhibitor.
Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis.
Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine.
Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents.
Release of ATP in the central nervous system during systemic inflammation: real-time measurement in the hypothalamus of conscious rabbits.
Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts.
Production of gamma-aminobutyric acid by Streptococcus salivarius subsp. thermophilus Y2 under submerged fermentation.
Blood vitamin concentrations in privately owned dogs fed non-standardized commercial diets and after intake of diets with specified vitamin concentrations.
Short communication: empirical and mechanistic evidence for the role of pyridoxal-5'-phosphate in the generation of methanethiol from methionine.
Enhanced food intake after stimulation of hypothalamic P2Y1 receptors in rats: modulation of feeding behaviour by extracellular nucleotides.
B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans.
Children of Latino immigrants, 4-8 years, in rural Nebraska are adequate in vitamin B-6.
Dietary intake of vitamin B6 and concentration of vitamin B6 in blood samples of German vegans.
Cloning and sequencing of the histidine decarboxylase gene from Photobacterium phosphoreum and its functional expression in Escherichia coli.
Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets.
Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase.
Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5'-phosphate as the inhibitor.
Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women.
Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis.
Inflammation causes tissue-specific depletion of vitamin B6.
Biochemical characterization of the Campylobacter jejuni Cj1294, a novel UDP-4-keto-6-deoxy-GlcNAc aminotransferase that generates UDP-4-amino-4,6-dideoxy-GalNAc.
Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.
Effects of chemical modification of lysine residues on the sweetness of lysozyme.
Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats.
Vitamin B6 deficiency decreases the glucose utilization in cognitive brain structures of rats.
Effect of vitamin B6 supplementation on degradation rates of short-lived proteins in human neutrophils.
Plasma folate as marker of folate status in epidemiological studies: the European Investigation into Cancer and Nutrition (EPIC)-Potsdam study.
Catabolism of leucine to branched-chain fatty acids in Staphylococcus xylosus.
Uptake, hydrolysis, and metabolism of pyridoxine-5'-beta-D-glucoside in Caco-2 cells.
Purification and characterization of a branched-chain amino acid aminotransferase from Lactobacillus paracasei subsp. paracasei CHCC 2115.
Modulation of feeding behaviour by blocking purinergic receptors in the rat nucleus accumbens: a combined microdialysis, electroencephalographic and behavioural study.
Tracking interactions that stabilize the dimer structure of starch phosphorylase from Corynebacterium callunae. Roles of Arg234 and Arg242 revealed by sequence analysis and site-directed mutagenesis.
Low vitamin B6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification.
Hydrolytic activity toward pyridoxine-5'-beta-D-glucoside in rat intestinal mucosa is not increased by vitamin B-6 deficiency: effect of basal diet composition and pyridoxine intake.
Nutritional risk assessment and obesity in rural older adults: a sex difference.
Improved vitamin B-6 status is positively related to lymphocyte proliferation in young women consuming a controlled diet.
Lactobacillus reuteri DSM 20016: purification and characterization of a cystathionine gamma-lyase and use as adjunct starter in cheesemaking.
Biosynthesis of iron-sulphur clusters is a complex and highly conserved process.
Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years.
Purification and partial gene sequence of the tyrosine decarboxylase of Lactobacillus brevis IOEB 9809.
Ginkgo seed poisoning.
Effect of vitamin B6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and S-adenosylmethionine in rat tissues.
Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification.
Assessment of vitamin B-6 status in young women consuming a controlled diet containing four levels of vitamin B-6 provides an estimated average requirement and recommended dietary allowance.
Renal insufficiency, vitamin B(12) status, and population attributable risk for mild hyperhomocysteinemia among coronary artery disease patients in the era of folic acid-fortified cereal grain flour.
Stability of vitamin B-6-dependent aminotransferase activity in frozen packed erythrocytes is dependent on storage temperature.
Effect of phosphate on stability of pyridoxal in the presence of lysine.
Effects of long-term parenteral administration of vitamin B6 on B6 status and some aspects of the glucose and protein metabolism of early-weaned piglets.
Determination of vitamin B(6) in cooked sausages.
Biogenic amine production by Lactobacillus.
Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning.
Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet.
Vitamin B-6 intakes and plasma B-6 vitamer concentrations of men and women, 19-50 years of age.
Fluctuations in dietary methionine intake do not alter plasma homocysteine concentration in healthy men.
Suppression of feeding-evoked dopamine release in the rat nucleus accumbens by the blockade of P(2) purinoceptors.
The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet.
Plasma B-6 vitamer changes following a 50-km ultra-marathon.
Relationship between alcohol and nutrient intakes and blood status indices of older people living in the UK: further analysis of data from the National Diet and Nutrition Survey of people aged 65 years and over, 1994/5.
Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements.
Thermal denaturation pathway of starch phosphorylase from Corynebacterium callunae: oxyanion binding provides the glue that efficiently stabilizes the dimer structure of the protein.
Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration.
Mechanism of thermal denaturation of maltodextrin phosphorylase from Escherichia coli.
Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over.
High performance liquid chromatography method for the determination of pyridoxal-5-phosphate in human plasma: how appropriate are cut-off values for vitamin B6 deficiency?
Age-related changes in adenosine 5'-triphosphate-induced constriction of isolated, perfused mesenteric arteries of rats.
Konjac mannan improves the vitamin B-6 status of rats fed a vitamin B-6-deficient diet.
The influence of dietary restriction on vitamin B-6 vitamer distribution and on vitamin B-6 metabolizing enzymes in rats.
Characterization of psychrophilic alanine racemase from Bacillus psychrosaccharolyticus.
Identification of the vitamers of vitamin B6 excreted by a yeast mutant growing in a glucose minimal culture medium.
ATP-induced, P2U purinoceptor-mediated constriction of isolated, perfused mesenteric beds of the rat.
Homocysteine as a risk factor for cardiovascular and related disease: nutritional implications.
Vitamin B-6 deficiency and level of dietary protein affect hepatic tyrosine aminotransferase activity in cats.
Purification and characterization of L-methionine gamma-lyase from brevibacterium linens BL2
Dietary and other determinants of vitamin B6 parameters.
Micronutrient status, with special reference to vitamin B6.
Simple high-performance liquid chromatographic method for the determination of all seven vitamin B6-related compounds.
Changes in vitamin B-6 status indicators of women fed a constant protein diet with varying levels of vitamin B-6.
alpha-1,4-D-glucan phosphorylase of gram-positive Corynebacterium callunae: isolation, biochemical properties and molecular shape of the enzyme from solution X-ray scattering.
NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme.
Effect of magnesium deficiency on vitamin B2 and B6 status in the rat.
Feeding experiments of pyridoxine derivatives as vitamin B6.
Zinc status in vitamin B6 deficiency.
Cloning and analysis of the gene for cystathionine gamma-synthase from Arabidopsis thaliana.
Comparative study of pyridoxine-alpha, beta-glucosides, and phosphopyridoxyl-lysine as a vitamin B6 nutrient.
Vitamin B-6 status indicators decrease in women consuming a diet high in pyridoxine glucoside.
Changes in the vitamin status of elderly Europeans: plasma vitamins A, E, B-6, B-12, folic acid and carotenoids. SENECA Investigators.
Vitamin B-6 status of women with a constant intake of vitamin B-6 changes with three levels of dietary protein.
Wine and headache.
Interrelationships between metabolism of glycogen phosphorylase and pyridoxal phosphate--implications in McArdle's disease.
Vitamin B-6 status during childhood: tracking from 2 months to 11 years of age.
Vitamin B-6 adequacy in neonatal nutrition: associations with preterm delivery, type of feeding, and vitamin B-6 supplementation.
Pyridoxine and pyridoxine-5'-beta-D-glucoside exert different effects on tissue B-6 vitamers but similar effects on beta-glucosidase activity in rats.
Tissue B-6 vitamer concentrations in rats fed excess vitamin B-6.
[Effect of the ketogenic diet for West syndrome into which early infantile epileptic encephalopathy with suppression-burst was evolved].
Nutritional status of elderly female nursing home residents; the effect of supplementation with a physiological dose of water-soluble vitamins.
Dietary protein quality alters ornithine decarboxylase activity but not vitamin B-6 nutritional status in rats.
Erythrocyte and plasma B-6 vitamer concentrations of long-term tobacco smokers, chewers, and nonusers.
Vitamin B-6 requirement and status assessment: young women fed a depletion diet followed by a plant- or animal-protein diet with graded amounts of vitamin B-6.
Pyridoxine-5'-beta-D-glucoside influences the short-term metabolic utilization of pyridoxine in rats.
Infant vitamin B-6 status changes with age and with formula feeding.
Variability in absorption lag time of pyridoxal phosphate under fasting and pre- and post-meal conditions.
Tryptophanase from Escherichia coli: catalytic and spectral properties in water-organic solvents.
Change in blood levels of vitamin B-6 derivatives in pregnant and lactating rats.
Interrelationships between riboflavin and vitamin B6 among elderly people (Dutch Nutrition Surveillance System).
Increased plasma pyridoxal-5'-phosphate when alkaline phosphatase activity is reduced in moderately zinc-deficient rats.
Changes in cystathionine gamma-lyase levels in rat liver during lactation.
Some pharmacokinetic considerations about homeostatic equilibrium of endogenous substances.
Pathological changes in platelet histamine oxidases in atopic eczema.
Consumption of a dehydrated ration for 31 days at moderate altitudes: status of zinc, copper, and vitamin B-6.
Effects of Caramel Colour III on the number of blood lymphocytes: a human study on Caramel Colour III immunotoxicity and a comparison of the results with data from rat studies.
Pyridoxine-5'-beta-D-glucoside affects the metabolic utilization of pyridoxine in rats.
Cloning and characterization of the P subunit of glycine decarboxylase from pea (Pisum sativum).
Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives.
The C-S lyases of higher plants: homogeneous beta-cystathionase of spinach leaves.
Insensitivity of the tryptophan-load test to marginal vitamin B-6 intake in rats.
Vitamin B-6 requirements of elderly men and women.
Vitamin status of pediatric patients receiving long-term peritoneal dialysis.
Inhibition of cytoplasmic aspartate aminotransferase from porcine heart by R and S isomers of aminooxysuccinate and hydrazinosuccinate.
Highly sensitive determination of PLP in human plasma with HPLC method.
Vitamin B-6: a status report.
Inhibition of human brain aromatic L-amino acid decarboxylase by cooked food-derived 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines.
A longitudinal study of pyridoxine and zinc supplementation of lactating women.
In vitro evidence for a relationship between magnesium and vitamin B-6.
Pyridoxine supplementation of lactating mothers: relation to maternal nutrition status and vitamin B-6 concentrations in milk.
Simple isocratic high-performance liquid chromatographic method for measuring pyridoxine kinase activity in crude biological extracts.
In vivo evidence for a vitamin B-6 requirement in carnitine synthesis.
The redox-cycling assay is not suited for the detection of pyrroloquinoline quinone in biological samples.
Response of B-6 vitamers in plasma, erythrocytes and tissues to vitamin B-6 depletion and repletion in the rat.
Evaluation of vitamin B-6 status and function of rats fed excess pyridoxine.
Vitamin B-6 requirement of growing kittens.
Plasma pyridoxal phosphate as indicator of vitamin B6 status in morbidly obese women after gastric restriction surgery.
Influence of vitamin B6 status on aspects of lead poisoning in rats.
The fate of dietary pyridoxine-beta-glucoside in the lactating rat.
Effect of age on changes in plasma, erythrocyte, and urinary B-6 vitamers after an oral vitamin B-6 load.
Bioavailability of vitamin B-6 from plant foods.
Gastric emptying rates of drug preparations. I. Effects of size of dosage forms, food and species on gastric emptying rates.
Nutritional evaluation of soldiers subsisting on meal, ready-to-eat operational rations for an extended period: body measurements, hydration, and blood nutrients.
Plasma pyridoxal phosphate concentrations of men fed different levels of vitamin B-6.
Vitamin E, vitamin B-6, vitamin B-12, and folate status of gastric bypass surgery patients.
Simple isocratic high-performance liquid chromatographic method for the separation of the six vitamers of vitamin B6.
The C-S Lyases of Higher Plants : Direct Comparison of the Physical Properties of Homogeneous Alliin Lyase of Garlic (Allium sativum) and Onion (Allium cepa).
Effect of different levels of oral pyridoxine supplementation on plasma pyridoxal-5'-phosphate and pyridoxal levels and urinary vitamin B-6 excretion.
Effects of perinatal vitamin B6 deficiency on dopaminergic neurochemistry.
Specific nutritional requirements of Lactobacilli spp. from meat.
Short-term taste behavior and copper/vitamin B-6 nutriture in Long-Evans rats.
Food dyes produce minimal effects on locomotor activity and vitamin B-6 levels in postweanling rats.
Effect of protein quality on vitamin B-6 status in the rat.
Vitamin B6 intake and plasma pyridoxal phosphate concentrations in the first 2 weeks of life.
Comparative vitamin B-6 bioavailability from tuna, whole wheat bread and peanut butter in humans.
Relative biological activity of nonphosphorylated vitamin B-6 compounds in the rat.
Vitamin nutrition in patients on continuous ambulatory peritoneal dialysis (CAPD).
Effects of food composition on the bioavailability of vitamin B-6 in the rat.
Availability of vitamin B6 and pantothenate in an average American diet in man.
The endocrine pancreas in pyridoxine deficient rats.
B6 vitamer analysis in human plasma by high performance liquid chromatography: a preliminary report.
The bioavailability of vitamin B6 in foods.
Effects of epsilon-pyridoxyllysine bound to dietary protein on the vitamin B-6 status of rats.
Vitamin B-6 activity for rats of epsilon-pyridoxyllysine bound to dietary protein.
Characterization of food binding of vitamin B-6 in orange juice.
Induction of pyridoxal phosphate-dependent enzymes in vitamin B-6 deficient rats.
Partial Purification and Some Properties of Tyrosine Phenol-Lyase from Aeromonas phenologenes ATCC 29063.
Adequacy of vitamin B6 supplementation during pregnancy: a prospective study.
Convulsive seizure induced by intracerebral injection of semicarbazide (an anti-vitamin B6) in the mouse.
l-Ornithine:2-Oxoacid Aminotransferase from Squash (Cucurbita pepo, L.) Cotyledons: Purification and Properties.
Pyridoxal phosphate values in premature infants.
Catalytic effect of metal ions on non-enzymatic transamination between pyridoxal phosphate and kynurenines.
Vitamin B 6 requirement of young adult women.

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PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	247.14366149902
Boiling Point	565 to 566°C @ 760 mm Hg
Flash Point TCC Value	296 °C TCC
logP (o/w)	-1.921 est
Solubility
alcohol	Yes
water, 1.193e+004 mg/L @ 25 °C (est)	Yes

Safety Information

Safety information


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 5900 mg/kg Drugs in Japan Vol. 6, Pg. 643, 1982. oral-mouse LD50 4640 mg/kg Drugs in Japan Vol. 6, Pg. 643, 1982. intravenous-mouse LD50 530 mg/kg Drugs in Japan Vol. 6, Pg. 643, 1982. oral-mammal (species unspecified) LD50 > 3000 mg/kg British Patent Document. Vol. #1172800 intramuscular-mouse LD50 1150 mg/kg BEHAVIORAL: ANTIPSYCHOTIC Pharmaceutical Chemistry Journal Vol. 15, Pg. 303, 1981.
Dermal Toxicity:
subcutaneous-rat LD50 850 mg/kg Drugs in Japan Vol. 6, Pg. 643, 1982. subcutaneous-mouse LD50 870 mg/kg Drugs in Japan Vol. 6, Pg. 643, 1982. subcutaneous-mammal (species unspecified) LD50 550 mg/kg British Patent Document. Vol. #1172800
Inhalation Toxicity:
Not determined

Safety in use information

Category:
nutrient supplements
Recommendation for pyridoxal 5’-phosphate usage levels up to:
	not for fragrance use.

Recommendation for pyridoxal 5’-phosphate flavor usage levels up to:
	not for flavor use.

Safety references

European Food Safety Authority (EFSA) reference(s):

Opinion on Pyridoxal 5-phosphate as a source for vitamin B6 added for nutritional purposes in food supplements - Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
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ClinicalTrials.gov:search

Daily Med:search

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EPA Substance Registry Services (TSCA):54-47-7

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :1051

National Institute of Allergy and Infectious Diseases:Data