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methyl ethoxypyrazine

Chemical Structure

General Material Information

Preferred name methyl ethoxypyrazine
Trivial Name 2-Ethoxymethylpyrazine
Short Description 2-methyl-3(or 5 or 6)-ethoxypyrazine
Formula C7 H10 N2 O
CAS Number 65504-94-1
FEMA Number 3569
ECHA Number 265-794-5
FDA UNII 8Z723WC955
Nikkaji Number J307.420J
MDL MFCD00038025
xLogP3-AA -0.20 (est)
NMR Predictor External link
JECFA Food Flavoring 793 2-methyl-3(or 5 or 6)-ethoxypyrazine
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 977044-46-4 ; 2-METHYL-(3 OR 5 OR 6)-ETHOXYPYRAZINE
Synonyms
  • 2-ethoxy-3-methylpyrazine and 2-ethoxy-5-methylpyrazine mixture
  • 2-ethoxy-3,5 or 6-methyl pyrazine
  • 2-ethoxy-3,5 or 6-methylpyrazine
  • 2-ethoxy-3,5,6-methyl pyrazine
  • 2-ethoxy-3(5/6)-methyl pyrazine
  • 2-ethoxy-5-methylpyrazine and 2-ethoxy-3-methylpyrazine mixture
  • 2-ethoxymethyl pyrazine
  • 2-( ethoxymethyl)pyrazine
  • 2-ethoxymethylpyrazine
  • 2-methyl-3,5(6)-ethoxypyrazine
  • 2-methyl-3,5(or 6)-ethoxypyrazine
  • 2-methyl-3(5 or 6)-ethoxypyrazine, mixture
  • 2-methyl-3(or 5 or 6)-ethoxypyrazine
  • methylethoxypyrazine
  • mixture of 2-ethoxy-3-methylpyrazine and 2-ethoxy-5-methylpyrazine
  • 2-(ethoxymethyl)pyrazine
  • Pyrazine, 2-ethoxymethyl-
  • 2-Ethoxymethylpyrazine

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

2-(ethoxymethyl)pyrazine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):103404
Pubchem (sid):135270052
Publications by US Patents
3,952,024 - Furfurylthioacetone
Certain 2,5-dimethyl-3-thiopyrazines

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 138.16990661621
Specific gravity @ 25 °C
Pounds per Gallon 8.604 to 8.662
Refractive Index 1.493 to 1.497 @ 20 °C
Boiling Point 175 to 176°C @ 760 mm Hg
Vapor Pressure 0.746 mmHg @ 25 °C
Flash Point TCC Value 65.56 °C TCC
logP (o/w) 0.671 est
Solubility
alcohol Yes
water Yes
water, 5.605e+004 mg/L @ 25 °C (est) Yes

Organoleptic Properties

Odor Type: Nutty
nutty, hazelnut, nut skin, almond, earthy, brown, pineapple
Luebke, William tgsc, (1998) At 0.10 % in propylene glycol. nutty hazelnut nut skin almond earthy brown pineapple
Flavor Type: Bitter
nutty, nut skin, hazelnut, earthy, roasted, almond, barley roasted barley, taco
Luebke, William tgsc, (1998) Nutty nut skin hazelnut earthy roasted almond roasted barley taco

Potential Uses

Applications
Odor purposes Earth
Flavoring purposes Almond toasted almond , Hazelnut , Nut , Pineapple

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for methyl ethoxypyrazine usage levels up to:
not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.055 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 11
Click here to view publication 11
average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -0.50000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: -2.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.50000
fruit ices: --
gelatins / puddings: -3.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

EPI System: View
AIDS Citations:Search
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EPA Substance Registry Services (TSCA):65504-94-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :103404
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(ethoxymethyl)pyrazine
Chemidplus:0065504941